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Apolipoprotein E genotypes in a group of elderly subjects of Spanish descent living in Mexico City.

dc.creatorCastelli, P.
dc.creatorSosa, A.L.
dc.creatorCampillo, C.
dc.creatorNicolini, H.
dc.creatorCruz-Fuentes, C.
dc.date.accessioned2017-06-29T04:27:46Z
dc.date.available2017-06-29T04:27:46Z
dc.date.issued2002es_ES
dc.identifier363es_ES
dc.identifier.issn1041-6102es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5054
dc.identifier.urihttps://doi.org/10.1017/S1041610202008487es_ES
dc.language.isoenges_ES
dc.relation14 (3) 291-300 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAgedes_ES
dc.subject.mesh80 And Overes_ES
dc.subject.meshAlzheimer Disease-Diagnosises_ES
dc.subject.meshAlzheimer Disease-Ethnologyes_ES
dc.subject.meshAlzheimer Disease-Geneticses_ES
dc.subject.meshApolipoproteins E-Geneticses_ES
dc.subject.meshCatchment Area (Health)es_ES
dc.subject.meshDiagnostic And Statistical Manual Of Mental Disorderses_ES
dc.subject.meshFemalees_ES
dc.subject.meshGene Frequencyes_ES
dc.subject.meshGenotypees_ES
dc.subject.meshHumanses_ES
dc.subject.meshInternational Classification Of Diseaseses_ES
dc.subject.meshMalees_ES
dc.subject.meshMexicoes_ES
dc.subject.meshEpidemiologyes_ES
dc.subject.meshMiddle Agedes_ES
dc.subject.meshNucleic Acid Amplification Techniqueses_ES
dc.subject.meshPrevalencees_ES
dc.subject.meshSpaines_ES
dc.subject.meshEthnologyes_ES
dc.titleApolipoprotein E genotypes in a group of elderly subjects of Spanish descent living in Mexico City.es_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartment of Psychiatric Genetics, Instituto Nacional de Psiquiatría Ramón de la Fuente, San Lorenzo Huipulco, México DF, México.es_ES
dc.relation.jnabreviadoINT PSYCHOGERIATRes_ES
dc.relation.journalInternational psychogeriatrics / IPAes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2002es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaThe association between the APOE gene and Alzheimer's disease and other forms of dementia has been widely documented, but its relevance as a genetic risk factor in specific ethnic groups other than Caucasians in the United States and Europe is limited. The aim of this work was to describe the distribution of the APOE genotype in 80 subjects of Spanish origin, over 60 years old, who were institutionalized in the Spanish Hospital of Mexico City. Thirty-eight subjects who met the DSM-IV and ICD-10 criteria for Alzheimer's disease or vascular dementia and 42 controls without dementia underwent genotyping. APOE epsilon allele frequencies were as follows: for affected individuals, epsilon2, 7.9%, epsilon3, 69.7%, and epsilon4, 22.4%; for controls, epsilon2, 4.8%, epsilon3, 91.6%, and epsilon4, 3.6%. The higher frequency of the epsilon4 allele in the affected group (chi2 = 14.5; df = 4, p = .006) confirms an association between this APOE molecular variant and dementia in elderly Spaniardses_ES


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