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Kainic acid modifies mu-receptor binding in young, adult, and elderly rat brain

dc.creatorPérez-Cruz, Claudia
dc.creatorRocha, Luisa
dc.date.accessioned2017-06-29T04:27:25Z
dc.date.available2017-06-29T04:27:25Z
dc.date.issued2002es_ES
dc.identifier358es_ES
dc.identifier.issn0272-4340es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5049
dc.identifier.urihttps://doi.org/10.1023/A:1021861108885es_ES
dc.language.isoenges_ES
dc.relation22 (5-6) 741-753 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAging-Metabolismes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAnimals, Newbornes_ES
dc.subject.meshBinding Sites-Drug effectses_ES
dc.subject.meshBinding Sites-Physiologyes_ES
dc.subject.meshBrain-Drug effectses_ES
dc.subject.meshBrain-Growth & developmentes_ES
dc.subject.meshBrain-Metabolismes_ES
dc.subject.meshConvulsants-Pharmacologyes_ES
dc.subject.meshDown Regulation-Drug effectses_ES
dc.subject.meshDown-Regulation-Physiologyes_ES
dc.subject.meshEnkephalin, Ala(2)-MePhe(4)-Gly(5)-Pharmacokineticses_ES
dc.subject.meshEpilepsy-Metabolismes_ES
dc.subject.meshEpilepsy-Physiopathologyes_ES
dc.subject.meshKainic Acid-Pharmacologyes_ES
dc.subject.meshMalees_ES
dc.subject.meshNeurons-Drug effectses_ES
dc.subject.meshNeurons-Metabolismes_ES
dc.subject.meshOpioid Peptides-Metabolismes_ES
dc.subject.meshRadioligand Assayes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshReceptors, Opioid, mu-Drug effectses_ES
dc.subject.meshReceptors, Opioid, mu-Metabolismes_ES
dc.subject.meshStatus Epilepticus-Chemically inducedes_ES
dc.subject.meshStatus Epilepticus-Metabolismes_ES
dc.subject.meshStatus Epilepticus-Physiopathologyes_ES
dc.subject.meshUp-Regulation-Drug effectses_ES
dc.subject.meshUp-Regulation-Physiologyes_ES
dc.subject.meshConvulsantses_ES
dc.subject.meshOpioid Peptideses_ES
dc.subject.meshReceptors, Opioid, mues_ES
dc.subject.meshEnkephalin, Ala(2)-MePhe(4)-Gly(5)-es_ES
dc.subject.meshKainic Acides_ES
dc.titleKainic acid modifies mu-receptor binding in young, adult, and elderly rat braines_ES
dc.typearticlees_ES
dc.contributor.affiliationDivisión de Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente: Av. México-Xochimilco 101, Mexico. D.F. C.P., 14370 Mexico.es_ES
dc.contributor.emailIrocha@mail.cinvestav.mx.es_ES
dc.relation.jnabreviadoCELL MOL NEUROBIOLes_ES
dc.relation.journalCellular and Molecular Neurobiologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2002es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1573-6830es_ES
dc.identifier.doi10.1023/A:1021861108885es_ES
dc.description.monthDices_ES
dc.description.abstractotrodiomaMu-receptor binding changes were evaluated following the kainic acid (KA)-induced status epilepticus (SE) in young, adult, and elderly animals. Male Wistar rats were used as follows: young rats (15 days old) were treated with KA (7 mg-kg) and sacrificed 72 h (YKA3d) or 35 days (YKA35d) after SE; adult (90 days old) (AKA1d and AKA40d) and elderly rats (1-year-old) (EKA1d and EKA40d) were injected with KA (10 mg-kg) and then sacrificed 24 h or 40 days following SE. Their brains were processed for an autoradiography assay for mu-receptors. The YKA3d group showed increased values in dentate gyrus (39%) and a decrease in substantia nigra (26%); YKA35d animals had a reduction in caudate putamen (29%) and in substantia nigra (20%). The AKA1d group exhibited increased mu-receptors in caudate putamen (49%), cingulate (415%), frontal (52%), and temporal (53%) cortices: substantia nigra (56%), dentate gyrus (48%). and CA2 field of hippocampus (53%). The AKA40d group showed increased values in sensorimotor cortex (45%), anterior (39%), medial (65%), basolateral (202%), and central (32%) amygdaloid nuclei; dentate gyrus (80%) as well as CA2 (80%) and CA3 (49%) fields of hippocampus. The EKA1d group presented decreased mu-receptor binding in piriform (16%) and enthorinal (22%) cortices as well as in anterior amygdala nucleus (17%). The EKA40d group showed reduced values in sensorimotor cortex (14%) and substantia nigra (27%). The present results indicate that the mu-binding changes following SE depend on the rate of brain maturationes_ES


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