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Participation of the lateral septal nuclei (LSN) in the antidepressant-like actions of progesterone in the forced swimming test (FST)

dc.creatorEstrada-Camarena, Erika
dc.creatorContreras, Carlos M.
dc.creatorSaavedra, Margarita
dc.creatorLuna-Baltazar, Iván
dc.creatorLópez-Rubalcava, Carolina
dc.date.accessioned2017-06-29T04:27:19Z
dc.date.available2017-06-29T04:27:19Z
dc.date.issued2002es_ES
dc.identifier357es_ES
dc.identifier.issn0166-4328es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5048
dc.identifier.urihttps://doi.org/10.1016/S0166-4328(02)00023-2es_ES
dc.language.isoenges_ES
dc.relation134 (1-2) 175-183 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleParticipation of the lateral septal nuclei (LSN) in the antidepressant-like actions of progesterone in the forced swimming test (FST)es_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto de Neuroetología, Universidad Veracruzana, Xalapa Ver., Mexico; Departamento de Farmacobiología, CINVESTAV-IPN, Calzada de los Tenorios 235, Col Granjas Coapa, Deleg Tlalpan, C.P. 14330 Mexico D.F., Mexicoes_ES
dc.contributor.emailclopez@conacyt.mxes_ES
dc.relation.jnabreviadoBEHAV BRAIN RESes_ES
dc.relation.journalBehavioural Brain Researches_ES
dc.identifier.placeAmsterdam, Holandaes_ES
dc.date.published2002es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.description.monthAgoes_ES
dc.description.abstractotrodiomaThe possible participation of lateral septal nuclei (LSN) in the antidepressant-like actions of progesterone was evaluated. The effect of different concentrations of progesterone (0.001, 0.01 and 0.1 M) or saline solution injected directly into the LSN of ovariectomised rats was determined using the forced swimming test (FST). In addition, the temporal course of progesterone (0.1 M) antidepressant-like actions was compared with that of the classical antidepressant imipramine (0.1 M). Finally, in order to establish the possible participation of the GABAA receptor in the antidepressant-like action of progesterone, the effect of pre-treatment with the GABAA antagonist picrotoxin (0.125 mg/kg, i.p.) was evaluated. Intraseptally administered progesterone produced a concentration-dependent decrease in immobility behaviour but did not modify locomotor activity. These antidepressant-like actions lasted 4 h, while those of imipramine lasted 72 h. Finally, progesterone-induced anti-immobility effect could be blocked by the systemic injection of picrotoxin. Present results reveal that LSN play a role in the antidepressant-like actions of progesterone that appear to be mediated by the GABAA receptor.es_ES
dc.subject.kwMembrana laterales_ES
dc.subject.kwAntidepresivoses_ES
dc.subject.kwProgesteronaes_ES
dc.subject.kwNado Forzadoes_ES
dc.subject.kwReceptor GABAes_ES
dc.subject.kwPicrotoxinaes_ES
dc.subject.koLateral-septumes_ES
dc.subject.koAntidepressantes_ES
dc.subject.koProgesteronees_ES
dc.subject.koForced swimming testes_ES
dc.subject.koGABAA receptores_ES
dc.subject.koPicrotoxines_ES


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