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Evidence for changes in brain enkephalin contents associated to male rat sexual activity

dc.creatorRodríguez-Manzo, G.
dc.creatorAsai, M.
dc.creatorFernández-Guasti, A.
dc.date.accessioned2017-06-29T04:27:15Z
dc.date.available2017-06-29T04:27:15Z
dc.date.issued2002es_ES
dc.identifier356es_ES
dc.identifier.issn0166-4328es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5047
dc.identifier.urihttps://doi.org/10.1016/S0166-4328(01)00371-0es_ES
dc.language.isoenges_ES
dc.relation131 (1-2) 47-55 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleEvidence for changes in brain enkephalin contents associated to male rat sexual activityes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Farmacobiología, Cinvestav, IPN, Calzada de los Tenorios 235, Col. Granjas Coapa, Deleg. Tlalpan, D.F. C.P. 14330, Mexicoes_ES
dc.contributor.emailgrodrigu@mail.cinvestav.mxes_ES
dc.relation.jnabreviadoBEHAV BRAIN RESes_ES
dc.relation.journalBehavioural Brain Researches_ES
dc.identifier.placeAmsterdam, Holandaes_ES
dc.date.published2002es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.description.monthAbres_ES
dc.description.abstractotrodiomaIndirect evidence suggests that ejaculation might activate endogenous opioid systems, which exert an inhibitory influence on male rat sexual behaviour. The objective of the present study was to search for putative long-term changes in the contents of immunoreactive (IR) Met-enkephalin (IR-Met), Leu-enkephalin (IR-Leu) and opioid octapeptide Met–Arg6–Gly7–Leu8 (IR-Oct) in specific brain areas, after the execution of different amounts of sexual activity. Additionally, basal contents of these enkephalins were compared between sexually active (SA) and persistent sexually inactive (SI) rats. Immunoreactivity to enkephalins was determined by radioimmunoanalysis, in the frontal cortex, the hypothalamus and midbrain of SA and SI rats, as well as 24 or 48 h after males had one ejaculation or copulated to exhaustion. Twenty-four hours after sexual activity, there was a generalized increase in enkephalin contents that returned to control values at the 48 h measurement in all brain areas, but the hypothalamus, where IR-Met and IR-Oct remained elevated. No differences in the magnitude of the changes were found between rats that ejaculated once and sexually satiated males. IR-Oct concentration in the hypothalamus of SI rats appeared significantly higher than in SA animals, with no differences in IR-Met and IR-Leu. Results give direct evidence of the activation of endogenous opioid systems by male rat sexual activity. The occurrence of long lasting increases in the contents of IR-Met and IR-Oct in the hypothalamus of rats that copulated was detected. Finally, an intrinsically elevated octapeptide concentration in the hypothalamus of SI rats was found.es_ES
dc.subject.kwInmunoreactividad encefalinaes_ES
dc.subject.kwComportamiento sexual de la rata machoes_ES
dc.subject.kwÁreas cerebraleses_ES
dc.subject.kwAgotamiento sexuales_ES
dc.subject.kwPersistencia de no-máteres_ES
dc.subject.koEnkephalin immunoreactivityes_ES
dc.subject.koMale rat sexual behavioures_ES
dc.subject.koBrain areases_ES
dc.subject.koSexual exhaustiones_ES
dc.subject.koPersistent non-materses_ES


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