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Association study of the serotonin transporter gene polymorphism in obsessive-compulsive disorder

dc.creatorCamarena, Beatriz
dc.creatorRinetti, Gina
dc.creatorCruz, Carlos
dc.creatorHernández, Sandra
dc.creatorDe la Fuente, Juan Ramón
dc.creatorNicolini, Humberto
dc.date.accessioned2017-06-29T04:26:57Z
dc.date.available2017-06-29T04:26:57Z
dc.date.issued2001es_ES
dc.identifier352es_ES
dc.identifier.issn1461-1457es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5043
dc.identifier.urihttps://doi.org/10.1017/S1461145701002516es_ES
dc.language.isoenges_ES
dc.relation4 (3) 269-272 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAssociation study of the serotonin transporter gene polymorphism in obsessive-compulsive disorderes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Genética Psiquiátrica, Instituto Nacional de Psiquiatría Ramón de a Fuente Muñiz, México D.F., 14370es_ES
dc.relation.jnabreviadoINT J NEUROPSYCHOPHARMACOLes_ES
dc.relation.journalThe International Journal of Neuropsychopharmacologyes_ES
dc.identifier.placeEnglandes_ES
dc.date.published2001es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1461-1457es_ES
dc.identifier.doi10.1017/S1461145701002516es_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaThe hypothesis implicating the serotonergic system in the pathophysiology of obsessive-compulsive disorder (OCD) is supported by the therapeutic efficacy of selective serotonin reuptake inhibitors (SSRIs). Since SSRIs act on the serotonin transporter (5-HTT), it has been suggested that the 5-HTT gene (SCL6A4) could be a good candidate for OCD. The SCL6A4 gene has a 44-bp insertion/deletion polymorphism in its promoter region (5-HTTLPR). Previous studies have revealed an association between OCD and the l allele. We analysed the 5-HTTLPR polymorphic system in 115 Mexican OCD patients and 136 controls. No significant association was found between l allele and OCD (chi2 = 1.54, d.f. = 1, p = 0.21). Furthermore, we assessed alternative methods that employ family-based designs in a sample of 43 trios. Haplotype-based haplotype relative risk and transmission disequilibrium analysis did not show a preferential transmission of l allele to OCD probands. Our results indicate the need to analyse larger samples using family-based methodses_ES
dc.subject.kwTrastorno obsesivo-compulsivoes_ES
dc.subject.kwGenéticaes_ES
dc.subject.kwMetabolismoes_ES
dc.subject.koObsessive-Compulsive Disorderes_ES
dc.subject.koGeneticses_ES
dc.subject.koMetabolismes_ES


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