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Anticonvulsant properties and bio-guided isolation of palmitone from leaves of Annona diversifolia

dc.creatorGonzález-Trujano, María Eva
dc.creatorNavarrete, Andrés
dc.creatorReyes, Benito
dc.creatorCedillo-Portugal, Ernestina
dc.creatorHong, Enrique
dc.date.accessioned2017-06-29T04:26:24Z
dc.date.available2017-06-29T04:26:24Z
dc.date.issued2001es_ES
dc.identifier345es_ES
dc.identifier.issn0032-0943es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5036
dc.identifier.urihttp://doi.org/10.1055/s-2001-11504es_ES
dc.language.isoenges_ES
dc.relation67 (2) 136-141 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAnticonvulsants-Isolation & purificationes_ES
dc.subject.meshAnticonvulsants-Pharmacologyes_ES
dc.subject.meshEpilepsy-Chemically inducedes_ES
dc.subject.meshHydrocarbons-Isolation & purificationes_ES
dc.subject.meshHydrocarbons-Pharmacologyes_ES
dc.subject.meshKetones-Isolation & purificationes_ES
dc.subject.meshKetones-Pharmacologyes_ES
dc.subject.meshMalees_ES
dc.subject.meshMicees_ES
dc.subject.meshMolecular Structurees_ES
dc.subject.meshMotor Activity-Drug effectses_ES
dc.subject.meshPentylenetetrazole-Pharmacologyes_ES
dc.subject.meshPentylenetetrazole-Toxicityes_ES
dc.subject.meshPlant Leaves-Chemistryes_ES
dc.subject.meshPlants, Medicinal-Chemistryes_ES
dc.subject.meshReflex-Drug effectses_ES
dc.subject.meshAnticonvulsantses_ES
dc.subject.meshHydrocarbonses_ES
dc.subject.meshKetoneses_ES
dc.subject.meshPentylenetetrazole-Palmitonees_ES
dc.titleAnticonvulsant properties and bio-guided isolation of palmitone from leaves of Annona diversifoliaes_ES
dc.typearticlees_ES
dc.contributor.affiliationFacultad de Química, Departamento de Farmacia. Universidad Nacional Autónoma de México, México D. F., México.es_ES
dc.relation.jnabreviadoPLANTA MEDes_ES
dc.relation.journalPlanta Medicaes_ES
dc.identifier.placeAlemaniaes_ES
dc.date.published2001es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1439-0221es_ES
dc.identifier.doi10.1055/s-2001-11504es_ES
dc.description.abstractotrodiomaThe activity-guided fractionation of the ethanol extract of leaves of Annona diversifolia Saff., led to the isolation of palmitone (16-hentriacontanone) as the only anticonvulsant active compound. This aliphatic ketone was highly effective to diminish pentylenetetrazole (PTZ)-induced clonic-tonic seizures and toxicity. Also, it produced a prolongation of the latency for onset of seizures and a reduction of the death rate produced by 4-aminopyridine (4-AP) and bicuculline (BIC). However, it was inactive to inhibit the kainic acid (KA)- and strychnine (STC)-induced seizures. Palmitone did not produce motor incoordination and loss of righting reflex which are used as signs of neurological impairment. Palmitone (ED50 = 1.85 mg-kg) proved to be a more potent antiepileptic drug against the PTZ-induced seizures than etosuximide (ED50 = 59.6 mg-kg), sodium valproate (ED50 = 63 mg-kg), and carbamazepine (ED50 > 300 mg-kg) and it was only four-fold less potent than diazepam (ED50 = 0.48 mg-kg). The pharmacological profile of palmitone suggests that this compound could be acting on the GABAergic inhibitory systemes_ES


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