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Orphanin-FQ/nociceptin inhibits kindling epileptogenesis and enhances hippocampal feed-forward inhibition

dc.creatorGutiérrez, R.
dc.creatorLeff, P.
dc.creatorRomo-Parra, H.
dc.creatorAcevedo, R.
dc.creatorAntón, B.
dc.date.accessioned2017-06-29T04:26:15Z
dc.date.available2017-06-29T04:26:15Z
dc.date.issued2001es_ES
dc.identifier343es_ES
dc.identifier.issn0306-4522es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5034
dc.identifier.urihttps://doi.org/10.1016/S0306-4522(01)00196-8es_ES
dc.language.isoenges_ES
dc.relation105 (2) 325-333 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleOrphanin-FQ/nociceptin inhibits kindling epileptogenesis and enhances hippocampal feed-forward inhibitiones_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Fisiología, Biofísica y Neurociencias, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México D.F., Mexicoes_ES
dc.contributor.emailgrafael@fisio.cinvestav.mxes_ES
dc.relation.jnabreviadoNEUROSCIes_ES
dc.relation.journalNeurosciencees_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2001es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.description.abstractotrodiomaThe role of Orphanin-FQ/nociceptin in synaptic plasticity was assessed by its potency in modulating kindling epileptogenesis in vivo, and feed-forward inhibition in hippocampal recordings in vitro. In addition, a specific rabbit antiserum against this peptide was obtained and the immunohistochemical distribution of nociceptin was determined in rat brain slices. After the establishment of kindling epilepsy, by daily electrical stimulation of the piriform cortex, the i.c.v. injection of nociceptin, 20 min before the kindling stimulation, was not able to block the generation of the generalized seizures, nor to alter their duration. However, the i.c.v. injection of nociceptin, 20 min before each stimulation along the kindling process, depressed its development in a dose-dependent manner. This effect was specific since the nociceptin antagonist [Phe1psi(CH2-NH)Gly2]NC(1-13)NH2, but not the broad-spectrum opiate antagonist, naloxone, was able to completely block nociceptin actions. The inhibitory role of nociceptin was assessed by in vitro recordings from entorhinal cortex-hippocampal slices. By single pulses applied over the Schaffer collaterals, we found that synaptic transmission was facilitated onto CA1, but using a paired-pulse protocol, we found that nociceptin potentiated feed-forward inhibition. The immunohistochemical data show that nociceptin is expressed in limbic cortical regions, including the piriform cortex and the hippocampus. Our results demonstrate that nociceptin exerts a modulatory role in limbic excitability and suggest that it provides an inhibitory control in the development of epilepsy by possibly inhibiting the spread of excitation through the system, by favoring feed-forward inhibition.es_ES
dc.subject.koAnimalses_ES
dc.subject.koDose-Response Relationshipes_ES
dc.subject.koDruges_ES
dc.subject.koElectric Stimulationes_ES
dc.subject.koEpilepsy-Metabolismes_ES
dc.subject.koEpilepsy-Pathologyes_ES
dc.subject.koEpilepsy-Physiopathologyes_ES
dc.subject.koHippocampus-Drug effectses_ES
dc.subject.koHippocampus-Metabolismes_ES
dc.subject.koHippocampus-Physiopathologyes_ES
dc.subject.koImmunohistochemistryes_ES
dc.subject.koKindlinges_ES
dc.subject.koNeurologices_ES
dc.subject.koNaloxone-Pharmacologyes_ES
dc.subject.koNarcotic Antagonists-Pharmacologyes_ES
dc.subject.koNeural Inhibition-Drug Effectses_ES
dc.subject.koNeural Inhibition-Physiologyes_ES
dc.subject.koNeurons-Drug Effectses_ES
dc.subject.koNeurons-Metabolismes_ES
dc.subject.koOlfactory Pathways-Cytologyes_ES
dc.subject.koOlfactory Pathways-Metabolismes_ES
dc.subject.koOpioid Peptides-Antagonists & Inhibitorses_ES
dc.subject.koOpioid Peptides-Immunologyes_ES
dc.subject.koOpioid Peptides-Metabolismes_ES
dc.subject.koOpioid Peptides-Pharmacologyes_ES
dc.subject.koPeptide Fragments-Pharmacologyes_ES
dc.subject.koRatses_ES
dc.subject.koWistares_ES
dc.subject.koSynaptic Transmission-Drug Effectses_ES


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