Mostrar el registro sencillo del ítem

Acute ethanol administration differentially modulates mu opioid receptors in the rat meso-accumbens and mesocortical pathways

dc.creatorMéndez, Milagros
dc.creatorLeriche, Mariana
dc.creatorCalva, Juan Carlos
dc.date.accessioned2017-06-29T04:26:05Z
dc.date.available2017-06-29T04:26:05Z
dc.date.issued2001es_ES
dc.identifier340es_ES
dc.identifier.issn0169-328Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5032
dc.identifier.urihttps://doi.org/10.1016/S0169-328X(01)00232-7es_ES
dc.language.isoenges_ES
dc.relation94 (1-2) 148–156 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAcute ethanol administration differentially modulates mu opioid receptors in the rat meso-accumbens and mesocortical pathwayses_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatr__a Ramón de la Fuente Muñiz, Subdirección de Investigaciones Cl__nicas, Calzada Méxicoes_ES
dc.relation.jnabreviadoMOL BRAIN RESes_ES
dc.relation.journalMolecular Brain Researches_ES
dc.identifier.placeNetherlandses_ES
dc.date.published2001es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn0169-328Xes_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaBiochemical and pharmacological evidence suggest that the dopaminergic mesolimbic system plays a key role in mediating the reinforcing properties of alcohol and other drugs of abuse. Alcohol reinforcement and high alcohol drinking behavior have been postulated to be partially mediated by a neurobiological mechanism involving the alcohol-induced activation of the endogenous opioid system. The aim of this work was to study the effect of the in vivo acute administration of ethanol on mu (_) opioid receptors in the rat dopaminergic meso-accumbens and mesocortical pathways by quantitative receptor autoradiography. [3H]DAMGO binding was significantly decreased in the ventral tegmental area (VTA) 30 min after ethanol administration. A small ethanol-induced reduction was observed in the shell region of the nucleus accumbens 1 h after exposure. In contrast, 2 h after ethanol administration, [3H]DAMGO binding was significantly increased in the frontal and prefrontal cortices. The observed changes correlated well with high ethanol plasma levels. Our results suggest that the reinforcing properties of ethanol may be partially mediated by mechanisms involving the ethanol-induced down- and up-regulation of _ receptors in the dopaminergic mesolimbic system. Mu receptors in the VTA and the frontal and prefrontal cortices may be involved in the in vivo acute responses to ethanol and could play a key role in modulating the dopaminergic activity of the mesocortical pathway in response to the drug. In contrast, the contribution of both _ and _ receptors in the nucleus accumbens might be relevant in these processeses_ES
dc.subject.koNeural basis of behaviores_ES
dc.subject.koDrugs of abuse: alcoholes_ES
dc.subject.kobarbiturates and benzodiazepineses_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem