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dc.creatorEhlers, Cindy L.
dc.creatorWall, Tamara L.
dc.creatorGarcía-Andrade, Consuelo
dc.creatorPhillips, Evelyn
dc.date.accessioned2017-06-29T04:25:57Z
dc.date.available2017-06-29T04:25:57Z
dc.date.issued2001es_ES
dc.identifier338es_ES
dc.identifier.issn0096-882Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5030
dc.identifier.urihttps://doi.org/10.15288/jsa.2001.62.562es_ES
dc.language.isoenges_ES
dc.relation62 (5) 562-570 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAdolescentes_ES
dc.subject.meshAge Factorses_ES
dc.subject.meshAlcoholism-Epidemiologyes_ES
dc.subject.meshAlcoholism-Geneticses_ES
dc.subject.meshAlpha rhythmes_ES
dc.subject.meshAnalysis of variancees_ES
dc.subject.meshBeta rhythmes_ES
dc.subject.meshChildes_ES
dc.subject.meshElectroencephalographyes_ES
dc.subject.meshFemalees_ES
dc.subject.meshHumanses_ES
dc.subject.meshIndians, North American-Geneticses_ES
dc.subject.meshMalees_ES
dc.subject.meshPhenotypees_ES
dc.subject.meshSex factorses_ES
dc.titleAuditory P3 findings in Mission Indian youthes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartment of Neuropharmacology, Scripps Research Institute, CVN-14, 10550 North Torrey Pines Road, La Jolla, California 92037es_ES
dc.relation.jnabreviadoJ STUD ALCOHOLes_ES
dc.relation.journalJournal of Studies on Alcoholes_ES
dc.date.published2001es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaAbstract: Objective: Native Americans have some of the highest rates of alcohol abuse and dependence, yet potential biological risk factors associated with the problem drinking seen in many tribes remain relatively unknown. In this study, the amplitude of the P3 component of the event-related potential (ERP), a measure associated with risk for alcoholism in European-American youth, was investigated in Mission Indians. Method: The study participants were Mission Indian children and adolescents (N = 68, 37 male) between the ages of 7 and 13 years. ERPs were collected using two auditory ’oddball’ paradigms: an easy and a difficult discrimination task. P3 amplitude and latency were statistically evaluated as a function of age, gender, degree of Native American heritage (NAH) and family history (FH) of alcohol dependence. Results: P3 latency was found to vary as a function of age and gender, with girls demonstrating greater decreases in latency with age than boys, suggesting a faster maturation time. Whereas there were no significant relationships between NAH and P3 latency, those participants with at least one alcoholic parent had longerP3 latencies elicited by the difficult auditory task. No significant relationships were found between P3 amplitude generated to the target tones and any of the variables (age, gender, FH, NAH), Conclusions: Mean P3 amplitudes and latencies obtained from these Mission Indian youth were within the range of those values reported in the literature for samples of children and adolescents of other ethnicities. Although the amplitude of the P3 ERP measure has been associated with FH of alcoholism in studies of predominantly European-American individuals, P3 amplitudes generated in response to these auditory tasks did not robustly differentiate Mission Indian children and adolescents who may be at higher risk for alcoholism from those presumed to be at lower risk.es_ES


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