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Strain Differences in the Behavioral Effects of Antidepressant Drugs in the Rat Forced Swimming Test

dc.creatorLópez-Rubalcava, Carolina
dc.creatorLucki, Irwin
dc.date.accessioned2017-06-29T04:24:16Z
dc.date.available2017-06-29T04:24:16Z
dc.date.issued2000es_ES
dc.identifier313es_ES
dc.identifier.issn0893-133Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5006
dc.identifier.urihttps://doi.org/10.1016/S0893-133X(99)00100-1es_ES
dc.language.isoenges_ES
dc.relation22 (2) 191-199 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleStrain Differences in the Behavioral Effects of Antidepressant Drugs in the Rat Forced Swimming Testes_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV and División de Investigaciones en Neurociencias, Instituto Mexicano de Psiquiatría. Apartado Postal 22026, México 1400 DF, México. Fax: (5) 513 04 32es_ES
dc.contributor.emailclopez@neuroserver.imp-neuro.edu.mx.es_ES
dc.relation.jnabreviadoNEUROPSYCHOPHARMACOLOGYes_ES
dc.relation.journalNeuropsychopharmacologyes_ES
dc.identifier.placeNew Yorkes_ES
dc.date.published2000es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaWistar–Kyoto (WKY) rats provide a model of stressinduced depressive behavior, because they show enhanced vulnerability to the effects of stressors. The present study examined differences in the behavioral response to different types of antidepressant drugs between WKY and Sprague–Dawley (SD) rats in the forced swimming test (FST). WKY rats displayed significantly greater immobility than SD rats during their exposure to the FST. The noradrenergic antidepressant, desipramine, produced a dose-dependent reduction of immobility and increase of climbing behavior in the SD rats. In WKY rats, desipramine reduced immobility at a lower dose and produced increases of both swimming and climbing behavior. The serotonergic compounds, fluoxetine and 8-OH-DPAT, produced dosedependent reductions of immobility and increases of swimming behavior in the FST in SD rats, but the response to the serotonergic drugs were blunted in WKY rats. These results indicate that genetic or constitutive differences may determine the distinct behavioral profiles for antidepressant compounds with selective pharmacological effects in different rat strains, and these effects may be related to genetic heterogeneity of antidepressant responses in depressed patients.es_ES
dc.subject.kwAntidepresivoses_ES
dc.subject.kwDiferencias de las cepases_ES
dc.subject.kwGenéticaes_ES
dc.subject.kwComportamientoes_ES
dc.subject.kwNado forzadoes_ES
dc.subject.koAntidepressantses_ES
dc.subject.koStrain differenceses_ES
dc.subject.koGeneticses_ES
dc.subject.koBehaviores_ES
dc.subject.koForced swimminges_ES


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