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Anxiolytic-like actions of toluene in the burying behavior and plus-maze tests: differences in sensitivity between 5-HT1B knockout and wild-type mice

dc.creatorLópez-Rubalcava, Carolina
dc.creatorHen, Rene
dc.creatorCruz, Silvia Lorenia
dc.date.accessioned2017-06-29T04:23:40Z
dc.date.available2017-06-29T04:23:40Z
dc.date.issued2000es_ES
dc.identifier303es_ES
dc.identifier.issn0166-4328es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4997
dc.identifier.urihttps://doi.org/10.1016/S0166-4328(00)00241-2es_ES
dc.language.isoenges_ES
dc.relation115 (1) 85-94 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAnxiolytic-like actions of toluene in the burying behavior and plus-maze tests: differences in sensitivity between 5-HT1B knockout and wild-type micees_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Terapeútica Experimental, Departamento de Farmacología y Toxicología, Cinvestav, P.O. Box 22026, México 14000 D.F., División de Neurociencias, Instituto Mexicano de Psiquiatría, México D.F.es_ES
dc.contributor.emailclopez@buzon.main.conacyt.mxes_ES
dc.relation.jnabreviadoBEHAV BRAIN RESes_ES
dc.relation.journalBehavioural Brain Researches_ES
dc.identifier.placeAmsterdam, Holandaes_ES
dc.date.published2000es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaThis paper compares the anxiolytic-like actions of toluene in two anxiety paradigms, the burying behavior and plus-maze tests, in 5-HT1B knockout (KO) and 129:Sv-ter wild-type (WT) mice. Static exposures were conducted in 29-l gas chromatographic jars. Animals were exposed to toluene (0, 1000, 2000 or 4000 ppm; n_8–12, each) for 30 min, and immediately after, tested in one of the anxiety paradigms. Motor coordination was evaluated in the rota-rod test in independent groups of mice. Toluene produced a dose-dependent decrease in anxiety-like levels in both anxiety paradigms and in both the strains. However, toluene exerted its effects at lower concentrations in KO mice than in the WT strain. These results cannot be attributed to a decrease in motor coordination since all the animals behaved similarly in the rota-rod test, regardless of the treatment. To discard any inherent difference in the nociception threshold between strains, mice were tested in the hot plate immediately after being exposed to either air or toluene. Toluene increased nociception in a similar fashion in both the strains. Our results suggest that 5-HT1B KO mice are more sensitive to those of toluene’s actions related to anxiety, but not to those related with motor coordination or nociception. Data are discussed in terms of toluene’s mechanisms of action and on differences between WT and KO animals.es_ES
dc.subject.kwToluenoes_ES
dc.subject.kw5-HT1B ratones knock-outes_ES
dc.subject.kwAnsiedades_ES
dc.subject.kwComportamiento de enterrares_ES
dc.subject.kwLaberinto elevado en cruzes_ES
dc.subject.koToluenees_ES
dc.subject.ko5-HT1B knockout micees_ES
dc.subject.koAnxietyes_ES
dc.subject.koBurying behaviores_ES
dc.subject.koElevated plus-mazees_ES


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