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Blockade of the anxiolytic action of 8-OH-DPAT in lactating rats

dc.creatorFernández-Guasti, A.
dc.creatorPicazo, O.
dc.creatorFerreira, A.
dc.date.accessioned2017-06-29T04:21:34Z
dc.date.available2017-06-29T04:21:34Z
dc.date.issued1998es_ES
dc.identifier265es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4959
dc.identifier.urihttps://doi.org/10.1016/S0091-3057(97)00392-4es_ES
dc.language.isoenges_ES
dc.relation59 (1) 45-50 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleBlockade of the anxiolytic action of 8-OH-DPAT in lactating ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV and Instituto Mexicano de Psiquiatría, México D.F., Méxicoes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology Biochemistry and Behaviores_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published1998es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/S0091-3057(97)00392-4es_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaThe anxiolytic action of 8-OH-DPAT (0.125, 0.5, and 0.75 mg-kg, I.P., -15 min) was evaluated in ovariectomized and 7-day lactating mother rats. This serotonergic anxiolytic produces a clear reduction in cumulative burying behavior and in freezing time (parameters denoting a reduction in anxiety levels) in ovariectomized subjects. However, in 7-day lactating mother rats, 8-OH-DPAT lacked its antianxiety effects. Additionally, as an extra parameter of the animal's emotionality the number of defecation bolus was registered. A reduction in this parameter in ovariectomized animals after 8-OH-DPAT (0.5 mg-kg) injection was found. This effect was also blocked in 7-day lactating rats. None of the doses of the compound tested altered the burying behavior latency (a parameter inversely representing the animal's reactivity). The general ambulatory behavior of ovariectomized subjects was significantly impaired at the highest dose (0.75 mg-kg) of 8-OH-DPAT. Lower doses did not alter this parameter or the number of times lines are crossed (a parameter denoting exploratory activity). Discussion is focused on the relationship between the activity of the serotonergic system and the secretion of prolactin in this periodes_ES
dc.subject.ko8-Hydroxy-2-(di-n-propylamino)tetralin-Pharmacologyes_ES
dc.subject.koAnalysis of Variancees_ES
dc.subject.koAnimalses_ES
dc.subject.koAnti-Anxiety Agents-Pharmacologyes_ES
dc.subject.koFemalees_ES
dc.subject.koLactation-Physiologyes_ES
dc.subject.koMotor Activity-Drug effectses_ES
dc.subject.koOvariectomyes_ES
dc.subject.koOvaryes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Wistares_ES
dc.subject.koSerotonin Receptor Agonistses_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.koSerotonin Receptor Agonistses_ES
dc.subject.ko8-Hydroxy-2-(di-n-propylamino)tetralines_ES


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