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Determinants of P3 amplitude and response to alcohol in Native American Mission Indians

dc.creatorEhlers, Cindy L.
dc.creatorGarcía-Andrade, Consuelo
dc.creatorWall, Tamara L.
dc.creatorSobel, David F.
dc.creatorPhillips, Evelyn
dc.date.accessioned2017-06-29T04:21:27Z
dc.date.available2017-06-29T04:21:27Z
dc.date.issued1998es_ES
dc.identifier263es_ES
dc.identifier.issn0893-133Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4957
dc.identifier.urihttps://doi.org/10.1016/S0893-133X(97)00160-7es_ES
dc.language.isoenges_ES
dc.relation18 (4) 282-292 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAcoustic stimulationes_ES
dc.subject.meshAdolescentes_ES
dc.subject.meshAdultes_ES
dc.subject.meshAlcohol drinking-Geneticses_ES
dc.subject.meshAlcohol drinking-Physiopathologyes_ES
dc.subject.meshAlcohol drinking-Psychologyes_ES
dc.subject.meshAlcoholism-Geneticses_ES
dc.subject.meshAlcoholism-Physiopathologyes_ES
dc.subject.meshAlcoholism-Psychologyes_ES
dc.subject.meshEvent-Related Potentials, P300-Geneticses_ES
dc.subject.meshEvent-Related Potentials, P300-Physiologyes_ES
dc.subject.meshHumanses_ES
dc.subject.meshIndians, North Americanes_ES
dc.subject.meshMalees_ES
dc.subject.meshPolymorphism, Genetices_ES
dc.subject.meshRisk factorses_ES
dc.titleDeterminants of P3 amplitude and response to alcohol in Native American Mission Indianses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartment of Neuropharmacology, Scripps Research Institute, San Diego, USA.es_ES
dc.relation.jnabreviadoNEUROPSYCHOPHARMACOLOGYes_ES
dc.relation.journalNeuropsychopharmacologyes_ES
dc.date.published1998es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1740-634Xes_ES
dc.description.abstractotrodiomaNative Americans have some of the highest rates of alcohol abuse and dependence, yet potential biological risk factors associated with the problem drinking seen in some tribes remain relatively unknown. The amplitude of the P3 component of the event-related potential (ERP) is perhaps the most studied electrophysiological "marker" of potential vulnerability to alcohol dependence, yet it has not been investigated in Native Americans. Forty-seven, non-alcohol-dependent Native American Mission Indian men between the ages of 18 and 25 years participated in the study. ERPs were collected at 60 minutes following both alcohol (0.56 g-kg) and placebo intake. No relationship was found between P3 amplitude and degree of Native-American heritage (NAH), or family history (FH) of alcohol dependence. The results of this study did, however, replicate previous findings that the P3 component of the ERP is sensitive to the effects of alcohol. A reduction in the P3a component across the scalp was found in these Native American men following alcohol when compared with placebo ingestion. P3 response to alcohol, although not influenced by a subject's NAH or FH, was influenced by the presence of a polymorphism in the alcohol metabolizing enzyme alcohol dehydrogenase (ADH). Men with an ADH2 x 3 allele had significantly higher amplitude P3 components at placebo and also demonstrated more alcohol-induced reductions in P3 amplitude than men with ADH2 x 1 alleles only. In addition, individuals with low P3 amplitude in the placebo condition had less of a reduction or an actual increase in P3a and P3b amplitudes following alcohol intake. Given that a less intense response to alcohol has been associated with greater risk for the development of alcohol-related problems, these data suggest the presence of certain biological variables within this Native American population that may confer both risk and protection for the future development of alcohol dependence.es_ES
dc.subject.kwP3es_ES
dc.subject.kwNativos Americanoses_ES
dc.subject.kwDependencia al alcoholes_ES
dc.subject.kwPotenciales evocados (ERPs)es_ES
dc.subject.koERPses_ES
dc.subject.koNative Americanses_ES
dc.subject.koAlcohol dependencees_ES
dc.subject.koP3es_ES


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