Mostrar el registro sencillo del ítem

NADPH-diaphorase-stained neurons after experimental epilepsy in rats

dc.creatorTalavera, E.
dc.creatorMartínez-Lorenzana, G.
dc.creatorCorkidi, G.
dc.creatorLéon-Olea, M.
dc.creatorCondés-Lara, M.
dc.date.accessioned2017-06-29T04:20:31Z
dc.date.available2017-06-29T04:20:31Z
dc.date.issued1997es_ES
dc.identifier247es_ES
dc.identifier.issn1089-8603es_ES
dc.identifier.urihttp://dx.doi.org/10.1006/niox.1997.0158es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4941
dc.language.isoenges_ES
dc.relation1 (6) 484-493 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleNADPH-diaphorase-stained neurons after experimental epilepsy in ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationCentro de Neurobiología and Laboratorio de Imágenes del Centro de Instrumentos, Universidad Nacional Autónoma de México, Querétaro, Méxicoes_ES
dc.relation.jnabreviadoNITRIC OXIDEes_ES
dc.relation.journalNitric oxide : Biology and Chemistryes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published1997es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1089-8611es_ES
dc.identifier.doi10.1006/niox.1997.0158es_ES
dc.description.monthDices_ES
dc.description.abstractotrodiomaThe aim of this study was to determine the neuronal participation of nitric oxide (NO) in experimental epilepsy. To reach this objective, we established the amount of cells presenting nitric oxide synthase (NOS) and the amygdaline concentrations in the L-arginine-nitric oxide synthesis pathway. A group of fully epileptic rats, induced by the kindling procedure and that had reached at least 10 generalized seizures, was studied. We evaluated behavioral stages, electroencephalographic activities, and histochemical NOS-positive cells and carried out high-pressure liquid chromatography (HPLC) determinations of arginine, citrulline, and glutamic acid. Our results showed that behavioral and electrographic frequency, and duration of epileptic activities, were increased during the kindling process. Image processing system of NOS cells showed two types of intensities in cell stains in hippocampus, caudate-putamen, and amygdala. When we independently counted the two types of NOS stain cells, a selective increase in the number and density of weak-stained cells was observed, while dark-stained cells did not change in the studied structures. Additionally, arginine, citrulline, and glutamic acid concentrations in amygdala increased in kindled animals. The differential and specific increase in the stained cells expressing the nitric oxide synthase, as well as the increase in concentrations of the L-arginine-nitric oxide pathway in amygdala, suggested a relationship with the progressive augmentation in the electrophysiological hyperactivity characteristic of generalized epilepsyes_ES
dc.subject.koAnimalses_ES
dc.subject.koArginine-Analysises_ES
dc.subject.koBehavior, Animales_ES
dc.subject.koBrain-Cytologyes_ES
dc.subject.koCitrulline-Analysises_ES
dc.subject.koElectric Stimulationes_ES
dc.subject.koElectrophysiologyes_ES
dc.subject.koEpilepsy, Generalized-Physiopathologyes_ES
dc.subject.koGlutamic Acid-Analysises_ES
dc.subject.koHistocytochemistryes_ES
dc.subject.koImage Processing, Computer-Assistedes_ES
dc.subject.koKindling, Neurologic-Physiologyes_ES
dc.subject.koMalees_ES
dc.subject.koNADPH Dehydrogenase-Metabolismes_ES
dc.subject.koNeurons-Enzymologyes_ES
dc.subject.koNitric Oxide-Physiologyes_ES
dc.subject.koNitric Oxide Synthase-Metabolismes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Wistares_ES
dc.subject.koNitric Oxidees_ES
dc.subject.koCitrullinees_ES
dc.subject.koGlutamic Acides_ES
dc.subject.koArgininees_ES
dc.subject.koNitric Oxide Synthasees_ES
dc.subject.koNADPH Dehydrogenasees_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem