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The multidrug resistance P-glycoprotein modulates cell regulatory volume decrease.

dc.creatorValverde, Miguel A.
dc.creatorBond, Tamara D.
dc.creatorHardy, Simon P.
dc.creatorTaylor, Jenny C.
dc.creatorHiggins, Cristopher F.
dc.creatorAltamirano, Julio
dc.creatorAlvarez-Leefmans, Francisco J.
dc.date.accessioned2017-06-29T04:19:54Z
dc.date.available2017-06-29T04:19:54Z
dc.date.issued1996es_ES
dc.identifier235es_ES
dc.identifier.issn0261-4189es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4929
dc.identifier.urihttps://doi.org/10.1002/j.1460-2075.1996.tb00823.xes_ES
dc.language.isoenges_ES
dc.relation15 (17) 4460-4468 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleThe multidrug resistance P-glycoprotein modulates cell regulatory volume decrease.es_ES
dc.typearticlees_ES
dc.contributor.affiliationNuffield Department of Clinical Biochemistry and Imperial Cancer Research Fund Laboratories, Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxfordes_ES
dc.relation.jnabreviadoEMBO Jes_ES
dc.relation.journalThe EMBO Journales_ES
dc.identifier.placeInglaterraes_ES
dc.date.published1996es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1460-2075es_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaCell volume is frequently down-regulated by the activation of anion channels. The role of cell swelling-activated chloride channels in cell volume regulation has been studied using the patch-clamp technique and a non-invasive microspectrofluorimetric assay for changes in cell volume. The rate of activation of these chloride channels was shown to limit the rate of regulatory volume decrease (RVD) in response to hyposmotic solutions. Expression of the human MDR1 or mouse mdr1a genes, but not the mouse mdr1b gene, encoding the multidrug resistance P-glycoprotein (P-gp), increased the rate of channel activation and the rate of RVD. In addition, P-gp decreased the magnitude of hyposmotic shock required to activate the channels and to elicit RVD. Tamoxifen selectively inhibited both chloride channel activity and RVD. No effect on potassium channel activity was elicited by expression of P-gp. The data show that, in these cell types, swelling-activated chloride channels have a central role in RVD. Moreover, they clarify the role of P-gp in channel activation and provide direct evidence that P-gp, through its effect on chloride channel activation, enhances the ability of cells to down-regulate their volumees_ES
dc.subject.koCell volumees_ES
dc.subject.koChloride channeles_ES
dc.subject.koP-glycoproteines_ES
dc.subject.koRegulatory volume decreasees_ES
dc.subject.koMultidrug resistancees_ES


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