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Age-dependent differences in the rat's conditioned defensive burying behavior: effect of 5-HT1A compounds

dc.creatorLópez-Rubalcava, Carolina
dc.creatorFernández-Guasti, Alonso
dc.creatorUrbá-Holmgren, Ruth
dc.date.accessioned2017-06-29T04:19:24Z
dc.date.available2017-06-29T04:19:24Z
dc.date.issued1996es_ES
dc.identifier225es_ES
dc.identifier.issn0012-1630es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4919
dc.identifier.urihttps://doi.org/10.1002/(SICI)1098-2302(199603)29:2<157::AID-DEV5>3.0.CO;2-Res_ES
dc.language.isoenges_ES
dc.relation29 (2) 157-169 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAge-dependent differences in the rat's conditioned defensive burying behavior: effect of 5-HT1A compoundses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Farmacologia y Toxicologia, CINVESTAV, Instituto Mexicano de Psiquiatria, Mexico D.F.es_ES
dc.relation.jnabreviadoDEV PSYCHOBIOLes_ES
dc.relation.journalDevelopmental Psychobiologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published1996es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1098-2302es_ES
dc.identifier.doi10.1002/(SICI)1098-2302(199603)29:2<157es_ES
dc.description.monthMares_ES
dc.description.abstractotrodiomaThe ontogeny of conditioned defensive-burying behavior was studied in rats from 2 to 21 weeks of age. At early ages this parameter shows low values that gradually increase until the 11th week, decreasing steadily thereafter. Reactivity, measured by the burying-behavior latency, appeared increased in 2-week-old rats. The effect of the serotonergic1A compounds: 8-OH-DPAT (0.25 and 0.5 mg/kg), ipsapirone, buspirone, and indorenate (at 2.5 and 5.0 mg/kg) was studied at 3, 7, 11, and 21 weeks of age. All compounds produced a dose-dependent decrease in burying behavior in rats of 7 and 11 weeks, while at the Week 21, only 8-OH-DPAT and indorenate reduced it. At 3 weeks of age, burying-behavior latency was increased by all compounds, but burying behavior was not altered. Motor coordination was affected by buspirone at all ages and by 8-OH-DPAT at the Week 21. Data are discussed on the bases of the development of defensive behaviorses_ES
dc.subject.koAging-Drug effectses_ES
dc.subject.koAnimalses_ES
dc.subject.koConditioning, Classical-Drug effectses_ES
dc.subject.koDose-Response Relationship, Druges_ES
dc.subject.koFear-Drug effectses_ES
dc.subject.koFemalees_ES
dc.subject.koMalees_ES
dc.subject.koMotor Activity-Drug effectses_ES
dc.subject.koMotor Skills-Drug effectses_ES
dc.subject.koRatses_ES
dc.subject.koRats, Wistares_ES
dc.subject.koReceptors, Serotonin-Drug effectses_ES
dc.subject.koSerotonin Agents-Pharmacologyes_ES
dc.subject.koStereotyped Behavior-Drug effectses_ES
dc.subject.koReceptors, Serotonines_ES
dc.subject.koSerotonin Agentses_ES


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