Mostrar el registro sencillo del ítem

Alcohol elimination in Native American Mission Indians: an investigation of interindividual variation

dc.creatorWall, T.L.
dc.creatorGarcía-Andrade, C.
dc.creatorThomasson, H.R.
dc.creatorCole, M.
dc.creatorEhlers, C.L.
dc.date.accessioned2017-06-29T04:19:15Z
dc.date.available2017-06-29T04:19:15Z
dc.date.issued1996es_ES
dc.identifier222es_ES
dc.identifier.issn0145-6008es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4916
dc.identifier.urihttps://doi.org/10.1111/j.1530-0277.1996.tb01105.xes_ES
dc.language.isoenges_ES
dc.relation20 (7) 1159-1164 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAdolescentes_ES
dc.subject.meshAdultes_ES
dc.subject.meshAlcohol dehydrogenase-Geneticses_ES
dc.subject.meshAlcoholism-Bloodes_ES
dc.subject.meshAlcoholism-Geneticses_ES
dc.subject.meshAlcoholism-Psychologyes_ES
dc.subject.meshAlleleses_ES
dc.subject.meshEthanol-Pharmacokineticses_ES
dc.subject.meshGenotypees_ES
dc.subject.meshHumanses_ES
dc.subject.meshIndians, North American-Geneticses_ES
dc.subject.meshIndians, North American-Psychologyes_ES
dc.subject.meshMalees_ES
dc.subject.meshMetabolic clearance rate-Geneticses_ES
dc.subject.meshPolymorphism, genetices_ES
dc.subject.meshReference Valueses_ES
dc.subject.meshRisk factorses_ES
dc.subject.meshSocial environmentes_ES
dc.titleAlcohol elimination in Native American Mission Indians: an investigation of interindividual variationes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartment of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA.es_ES
dc.relation.jnabreviadoALCOHOL CLIN EXP RESes_ES
dc.relation.journalAlcoholism Clinical And Experimental Researches_ES
dc.identifier.placePhiladelphiaes_ES
dc.date.published1996es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1530-0277es_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaThe high prevalence of alcohol abuse and alcohol dependence among Native Americans may be mediated by unique environmental and genetic factors in this population. One factor that may influence the development of alcoholism is variability in alcohol metabolism. To determine factors that contribute to differences in alcohol elimination rates within a Native American population, this study evaluated healthy southern California Mission Indian men between the ages of 18 and 25 years. Each man drank a dose of alcohol, 0.56 g-kg of body weight as a 20% by volume solution, at approximately 9:00 AM after eating a low-fat breakfast and having fasted overnight. The drink was consumed within 7 min, and the concentrations of alcohol in blood were determined before and at 15, 30, 60, 90, 120, and 150 min after beverage ingestion. Rates of alcohol elimination were calculated from the pseudolinear slope of the blood alcohol versus time curve. The influences of estimated body water, recent drinking history, recent smoking history, polymorphism at the ADH2 and ADH3 loci, family history of alcoholism, and percentage Native American heritage on alcohol elimination rate were determined using multiple regression analyses. Estimated body water accounted for a significant proportion of the variance in alcohol elimination rate. There was also a nonsignificant trend for subjects with an ADH2*3 allele (n = 6) to have faster rates of alcohol elimination than those with ADH2*1 alleles only (n = 33). Given the high prevalence of alcoholism and alcohol-related health problems among Native Americans, the results from this study suggest that evaluation of alcohol metabolism and genotypes of the alcohol-metabolizing enzymes in Native American populations merits further study.es_ES
dc.subject.kwAlcohol deshidrogenasaes_ES
dc.subject.kwGenotipoes_ES
dc.subject.kwIndios Nativos Americanoses_ES
dc.subject.kwMetabolismoes_ES
dc.subject.koAlcohol dehydrogenasees_ES
dc.subject.koGenotypees_ES
dc.subject.koNative American Indianses_ES
dc.subject.koMetabolismes_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem