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Opioid antagonists and the sexual satiation phenomenon

dc.creatorRodríguez-Manzo, G.
dc.creatorFernández-Guasti, A.
dc.date.accessioned2017-06-29T04:18:43Z
dc.date.available2017-06-29T04:18:43Z
dc.date.issued1995es_ES
dc.identifier211es_ES
dc.identifier.issn0033-3158es_ES
dc.identifier.urihttp://link.springer.com/article/10.1007/BF02246087es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4905
dc.language.isoenges_ES
dc.relation122 (2) 131-136 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleOpioid antagonists and the sexual satiation phenomenones_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Terapeútica Experimental, Departamento de Farmacología, CINVESTAV and División de Investigaciones en Neurociencias, Instituto Mexicano de Psiquiatría, México D.F., Méxicoes_ES
dc.relation.jnabreviadoPSYCHOPHARMACOLOGYes_ES
dc.relation.journalPsychopharmacologyes_ES
dc.identifier.placeAlemaniaes_ES
dc.date.published1995es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1432-2072es_ES
dc.identifier.doi10.1007/BF02246087es_ES
dc.description.monthNoves_ES
dc.description.abstractotrodiomaThis study evaluates the effects of the IP injection of naloxone (0.3, 3 and 30 mg-kg) and naltrexone (0.2, 2 and 20 mg-kg) on the sexual satiation phenomenon. It was found that both antagonists exert a dose-based biphasic effect on the proportion of sexually exhausted rats displaying copulation. The intermediate doses of both opioid antagonists were more effective than the low and high doses in increasing the percentage of animals engaged in copulation. The analysis of the specific sexual behaviour parameters revealed that naloxone produces a slight inhibitory effect at the lowest dose, evidenced as an increase in the intromission number. The higher doses of this compound facilitated copulation reflected as a shortening of the ejaculation latency and the interintromission interval (III) and an increase in the copulatory rate. Naltrexone treatment had only facilitatory effects at the lower doses by reducing the III. The higher doses of naloxone (3 and 30 mg-kg) and the intermediate dose of naltrexone (2 mg-kg) decreased the spontaneous ambulatory behaviour of sexually satiated rats without impairing sexual behaviour execution. Data suggest a participation of the endogenous opioid systems in the sexual inhibition resulting from sexual exhaustiones_ES
dc.subject.kwMale sexual behavioures_ES
dc.subject.kwSexual exhaustiones_ES
dc.subject.kwOpioid antagonistses_ES
dc.subject.koAnimalses_ES
dc.subject.koCopulationes_ES
dc.subject.kodrug effectses_ES
dc.subject.koEjaculationes_ES
dc.subject.koMalees_ES
dc.subject.koMotor Activityes_ES
dc.subject.koNaloxonees_ES
dc.subject.kopharmacologyes_ES
dc.subject.koNaltrexonees_ES
dc.subject.koNarcotic Antagonistses_ES
dc.subject.koRatses_ES
dc.subject.koRats, Wistares_ES
dc.subject.koSatiety Responsees_ES
dc.subject.koSexual Behavior, Animales_ES
dc.subject.kodrug effectses_ES
dc.subject.koNarcotic Antagonistses_ES


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