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Penicillin-G induced interictal activity increases both opioid peptide tissue content and in vitro release in the rat brain

dc.creatorAsai, M.
dc.date.accessioned2017-06-29T04:18:38Z
dc.date.available2017-06-29T04:18:38Z
dc.date.issued1995es_ES
dc.identifier209es_ES
dc.identifier.issn0143-4179es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/0143-4179(95)90019-5es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4903
dc.language.isoenges_ES
dc.relation29 (3) 163-170 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titlePenicillin-G induced interictal activity increases both opioid peptide tissue content and in vitro release in the rat braines_ES
dc.typearticlees_ES
dc.contributor.affiliationDivisión de Investigación en Neurociencias, Instituto Mexicano de Psiquiatría, Fac. Psychol, UNAM, México D.F., México.es_ES
dc.relation.jnabreviadoNEUROPEPTIDESes_ES
dc.relation.journalNeuropeptideses_ES
dc.identifier.placeEscociaes_ES
dc.date.published1995es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1532-2785es_ES
dc.identifier.doi10.1016/0143-4179(95)90019-5es_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaPenicillin-G has been used as a common agent to produce epileptic foci and interictal activity. The development of the interictal spikes has been associated with enhanced inhibitory effects. There is evidence that the opioid peptides play an important role in the production of some transient postictal behaviors. In order to test whether enkephalins are involved during the interictal activity, we analyzed immunoreactive met- and leu-enkephalin content and their release in vitro, after the injection of 50 IU of penicillin-G into the left amygdala. Male Wistar rats were injected once daily for 5 days, and sacrificed by decapitation (15 min after the penicillin-G infusion) on the fifth day. The rats were divided into two groups: 1. In one group we analyzed the tissue content of enkephalins in hypothalamus, hippocampus, amygdala, striatum and cerebral cortext. 2. The second group was used for the assessment of the in vitro release of enkephalins from amygdala slices. In the amygdala, the drug treatment produced an increase in the tissue content of IR-ME. No changes occurred in the other structures. The content of IR-Leu-enkephalin increased in all structures analyzed except the cerebral cortex. In vitro release of both enkephalins increased in drug treated animals. These results suggest that the enkephalins could be involved in postictal mechanisms, as a result of repetitive interictal spikinges_ES
dc.subject.koAmino Acid Sequencees_ES
dc.subject.koAmygdalaes_ES
dc.subject.kodrug effectses_ES
dc.subject.koAmygdalaes_ES
dc.subject.kometabolismes_ES
dc.subject.koAnimalses_ES
dc.subject.koBraines_ES
dc.subject.kodrug effectses_ES
dc.subject.koBraines_ES
dc.subject.kometabolismes_ES
dc.subject.koConvulsantses_ES
dc.subject.koEnkephalin, Leucinees_ES
dc.subject.kometabolismes_ES
dc.subject.koEnkephalin, Methioninees_ES
dc.subject.kometabolismes_ES
dc.subject.koEvoked Potentialses_ES
dc.subject.kodrug effectses_ES
dc.subject.koMalees_ES
dc.subject.koMolecular Sequence Dataes_ES
dc.subject.koPenicillin Ges_ES
dc.subject.koRatses_ES
dc.subject.koRats, Wistares_ES
dc.subject.koTime Factorses_ES
dc.subject.koConvulsantses_ES
dc.subject.koEnkephalin, Methioninees_ES
dc.subject.koEnkephalin, Leucinees_ES
dc.subject.koPenicillin Ges_ES


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