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Anti-anxiety effects of progesterone and some of its reduced metabolites: an evaluation using the burying behavior test

dc.creatorPicazo, O.
dc.creatorFernández-Guasti, A.
dc.date.accessioned2017-06-29T04:18:15Z
dc.date.available2017-06-29T04:18:15Z
dc.date.issued1995es_ES
dc.identifier201es_ES
dc.identifier.issn0006-8993es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4895
dc.identifier.urihttps://doi.org/10.1016/0006-8993(95)00254-Nes_ES
dc.language.isoenges_ES
dc.relation680 (1-2) 135-141 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAnti-anxiety effects of progesterone and some of its reduced metabolites: an evaluation using the burying behavior testes_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV, Ap. Postal 22026, 14000 México, D.F., México y División de Investigaciones en Neurociencias, IMP, Cinco de Mayo 29, Col. Pueblo de Tepepan, 16020 México, D.F., Méxicoes_ES
dc.relation.jnabreviadoBRAIN RESes_ES
dc.relation.journalBrain researches_ES
dc.identifier.placeAmsterdam, Holandaes_ES
dc.date.published1995es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaIn this study, pregnenolone sulfate, progesterone and some of its main reduced metabolites were tested for anxiolytic properties in rats using the burying behavior paradigm. All steroids were subcutaneously injected. Progesterone (0.5, 1.0, 2.0 and 4.0 mg/rat) and its 3t~-5a-reduced metabolite (0.125, 0.250, 0.5 and 1.0 mg/rat) produced a clear dose-dependent anxiolytic response, without affecting the spontaneous ambulatory behavior. 5a-Pregnanedione decreased burying behavior only at the highest dose (4.0 mg/rat). Pregnenolone sulfate (1.0, 2.0 and 4.0 mg/rat), 5/3-pregnanedione and 3/3- or 5/3-pregnanolones were devoid of effects. The 3/3-5/3-reduced metabolite of progesterone (2.0 and 4.0 mg/rat) decreased motor activity, without altering the burying behavior. These results demonstrate that the 3t~-5a metabolite of progesterone shows the highest anxiolytic potency in the burying behavior test, when compared with all steroids evaluated. The data are discussed in terms of the close structure-activity relationship requirements of steroids to stimulate the GABA/benzodiazepine receptor-chloride ionophore complex.es_ES
dc.subject.kwEsteroideses_ES
dc.subject.kwAnsiedades_ES
dc.subject.kwActividad motoraes_ES
dc.subject.kwComportamiento de enterrares_ES
dc.subject.kwRatases_ES
dc.subject.kwProgesteronaes_ES
dc.subject.kw3_-Hydroxy-5_-pregnan-20-onees_ES
dc.subject.koSteroides_ES
dc.subject.koAnxietyes_ES
dc.subject.koMotor activityes_ES
dc.subject.koBurying behaviores_ES
dc.subject.koRates_ES
dc.subject.ko3_-Hydroxy-5_-pregnan-20-onees_ES
dc.subject.koProgesteronees_ES


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