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Changes in TRH and its degrading enzyme pyroglutamyl peptidase II, during the development of amygdaloid kindling

dc.creatorDe Gortari, Patricia
dc.creatorFernández-Guardiola, Augusto
dc.creatorMartínez, Adrián
dc.creatorCisneros, Miguel
dc.creatorJoseph-Bravo, Patricia
dc.date.accessioned2017-06-29T04:18:12Z
dc.date.available2017-06-29T04:18:12Z
dc.date.issued1995es_ES
dc.identifier200es_ES
dc.identifier.issn0006-8993es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4894
dc.identifier.urihttps://doi.org/10.1016/0006-8993(95)00237-Kes_ES
dc.language.isoenges_ES
dc.relation679 (1) 144-150 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleChanges in TRH and its degrading enzyme pyroglutamyl peptidase II, during the development of amygdaloid kindlinges_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, MOR. 62271, Méxicoes_ES
dc.contributor.emailjoseph@pbr322.ceingebi.unam.mx.es_ES
dc.relation.jnabreviadoBRAIN RESes_ES
dc.relation.journalBrain researches_ES
dc.identifier.placeAmsterdam, Holandaes_ES
dc.date.published1995es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaPyroglutamyl peptidase II (PPII) is a neuronal ectoenzyme responsible for thyrotropin releasing hormone (TRH) degradation at the synaptic cleft. PPII, heterogeneously distributed in different brain regions and adenohypophysis, is regulated under various endocrine conditions where TRH is involved in thyrotropin or prolactin regulation but only at the adenohypophyseal level. TRH can downregulate PPII activity in cultured adenohypophyseal cells. TRH present in extrahypothalamic brain areas has been postulated to serve as a neuromodulator and levels of this peptide increase in amygdala, hippocampus and cortex after electrical stimulation (kindling or electroshock). To study whether brain PPII could be regulated in conditions that stimulate TRHergic neurons, TRH and PPII activity were determined during the development of amygdaloid kindling in the rat. TRH levels increased from stage II to V in amygdala and hippocampus in the ipsi- and contralateral side to stimulation. In n. accumbens a decrease, compared to sham was observed at stage II, but levels raised through stage V. In contrast, PPII activity was increased at stage II, in amygdala of both sides and in hippocampus, frontal cortex, n. accumbens and hypothalamus of the contralateral side; levels decreased at stage V to sham values in most structures (except amygdala and hippocampus where the activity was 30% below controls). These results suggest that PPII activity in the central nervous system can be regulated in conditions known to affect TRHergic neurons.es_ES
dc.subject.kwHormona liberadora de tirotropinaes_ES
dc.subject.kwPyroglutamyl peptidase IIes_ES
dc.subject.kwDespertares_ES
dc.subject.kwEctopeptidasees_ES
dc.subject.kwNeuropéctidoes_ES
dc.subject.koThyrotropin releasing hormonees_ES
dc.subject.koPyroglutamyl peptidase IIes_ES
dc.subject.koKindlinges_ES
dc.subject.koEctopeptidasees_ES
dc.subject.koNeuropeptidees_ES


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