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The dopamine D2 receptor gene TaqI A1 polymorphism and alcoholism in a Mexican population

dc.creatorCruz, C
dc.creatorCamarena, B
dc.creatorMejía, JM
dc.creatorPáez, F
dc.creatorEroza, V
dc.creatorRamón De La Fuente, J
dc.creatorKershenobich, D
dc.creatorNicolini, H
dc.date.accessioned2017-06-29T04:18:07Z
dc.date.available2017-06-29T04:18:07Z
dc.date.issued1995es_ES
dc.identifier198es_ES
dc.identifier.issn0188-4409es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4892
dc.language.isoenges_ES
dc.relation26(4) 421-426 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleThe dopamine D2 receptor gene TaqI A1 polymorphism and alcoholism in a Mexican populationes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Genética Molecular Psiquiátrica, PUIS-Instituto Mexicano de Psiquiatría, SS, México, D.F.es_ES
dc.relation.jnabreviadoARCH MED RESes_ES
dc.relation.journalArchives of Medical Researches_ES
dc.identifier.placeMéxicoes_ES
dc.date.published1995es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.description.abstractotrodiomaThe suggested association between the TaqI A1 allele of the dopamine D2 receptor (DRD2) gene with alcoholism was studied comparing the genotypes of 38 controls and 38 ethnic matched alcoholics, drawn from the Mexican population. The alcoholics in our sample suffered from one of the following conditions: delirium tremens, alcohol hallucinosis or uncomplicated alcohol withdrawal. Eighty-eight percent of the controls carried the A1 allele. The frequency of the DRD2 A1 allele in the Mexican sample was higher than reported in Caucasians, but similar to those described in Amerindian groups. There was not any difference in the prevalence or allele frequency between alcoholics and controls. Also, there was no significant differences when alcoholics were subtyped according to severity, age of onset, or positive family history. Alcoholics showed higher scores than controls in the neuroticism and psychoticism subscales on the Eysenck Personality Inventory. However, no relationship between personality traits and genotypes was found. Our results do not support a consistent association between the D2 receptor gene and alcoholism.es_ES


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