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Chronic pretreatment with naloxone modifies benzodiazepine receptor binding in amygdaloid kindled rats

dc.creatorRocha, L.
dc.creatorAckermann, R.F.
dc.creatorChugani, H.T.
dc.creatorEngel Jr., J.
dc.date.accessioned2017-06-29T04:17:36Z
dc.date.available2017-06-29T04:17:36Z
dc.date.issued1994es_ES
dc.identifier185es_ES
dc.identifier.issn0920-1211es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4879
dc.identifier.urihttps://doi.org/10.1016/0920-1211(94)90013-2es_ES
dc.language.isoenges_ES
dc.relation17 (2) 135-143 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleChronic pretreatment with naloxone modifies benzodiazepine receptor binding in amygdaloid kindled ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartments of aNeurology, UCLA, Los Angeles. CA, USA and Instituto Mexicano de Psiquiatría, México DF, Méxicoes_ES
dc.relation.jnabreviadoEPILEPSY RESes_ES
dc.relation.journalEpilepsy Researches_ES
dc.identifier.placeAmsterdam, Holandaes_ES
dc.date.published1994es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaMale Sprague-Dawley rats received either naloxone (75 pg/h) or saline (0.5 ,ul/h) S.C. for 14 days delivered with osmotic minipumps. Two days after termination of either treatment, daily amygdala kindling stimulation was applied until the animals experienced stage V kindled seizures. Benzodiazepine (BDZ) binding sites were labeled with [3H]flunitrazepam (2 nM), and changes in specific brain areas were determined by in vitro quantitative autoradiography. Twenty-four hours after the last electrical stimulation, the saline pretreated fully kindled rats showed enhanced BDZ receptor binding in dentate gyrus, and decreased binding in cingulate cortex ipsilateral to the stimulation compared to saline controls. Twenty-eight days after the last stage V kindled seizure, the significant alterations were no longer evident. In agreement with a previous study, we found that naloxone pretreated amygdale kindled rats showed stage V kindled seizures followed by intervals of 3-5 days in which the same electrical stimulation failed to induc.e any behavioral and EEG alterations. In comparison with the saline pretreated kindled and saline control groups, the naloxone pretreated kindled rats had significantly higher BDZ binding in different cortical areas, amygdala complex, hippocampus, substantia nigra and periaqueducta1 gray, 24 h after the last electrical stimulation. The present study indicates that previous chronic exposure to naloxone increases BDZ receptor binding in kindied rats, and suggests that this effect may be associated with the enhanced seizure suppression observed in these animals.es_ES
dc.subject.kwReceptores de las benzodiazepinases_ES
dc.subject.kwDespertares_ES
dc.subject.kwNaxolonaes_ES
dc.subject.kwSupresión de apoderamientoes_ES
dc.subject.koBenzodiazepine receptorses_ES
dc.subject.koKindlinges_ES
dc.subject.koNaloxonees_ES
dc.subject.koSeizure suppressiones_ES


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