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Ejaculation induced changes in escape latency in the hot plate test: pharmacological analysis of anxiolytic versus analgesic effect

dc.creatorSaldívar-González, A.
dc.creatorFernández-Guasti, A.
dc.date.accessioned2017-06-29T04:17:26Z
dc.date.available2017-06-29T04:17:26Z
dc.date.issued1994es_ES
dc.identifier181es_ES
dc.identifier.issn0166-4328es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4875
dc.identifier.urihttps://doi.org/10.1016/0166-4328(94)90147-3es_ES
dc.language.isoenges_ES
dc.relation60 (2) 191-198 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleEjaculation induced changes in escape latency in the hot plate test: pharmacological analysis of anxiolytic versus analgesic effectes_ES
dc.typearticlees_ES
dc.contributor.affiliationDivisión de Investigaciones en Neurociencias. Instituto Mexicano de Psiquiatría y Sección de Terapéutica Experimental. Departamento de Farmacología CINVESTAV, México D.F., Méxicoes_ES
dc.relation.jnabreviadoBEHAV BRAIN RESes_ES
dc.relation.journalBehavioural Brain Researches_ES
dc.identifier.placeAmsterdam, Holandaes_ES
dc.date.published1994es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaThe possible changes in nociception at various stages of male sexual behaviour were explored in the hot plate test. Although other authors have reported an antinociceptive effect of mating, we failed to find this effect on the hot plate test after several sexual behavior events. To further explore the possible antinociceptive action of copulation we administered a suboptimal analgesic dose of morphine (0.3 mg/kg i.p.). No change in nociception were observed in animals treated with a subthreshold dose of morphine and tested in the nociception test after ejaculation were observed. Since previous reports have refered that ejaculation produces hypoalgesia when measured in the hot plate test, we attempted to replicate these findings. We found that one ejaculation produces an increase in the latency to escape in male rats previously habituated to the hot plate test. These results suggest a hypoalgesic effect. However, such changes could also be interpreted as alterations in the animals' emotionality. Thus, a group of habituated animals was tested on the switched off plate. An important increase in the escape latency behaviour after ejaculation was observed, while no differences between control animals, without sexual behaviour display, tested on switched on and switched off plate were observed. The participation of the benzodiazepine and opiod systems in the ejaculation effect on the switched off plate was explored. A similar increase in escape latency to that induced by ejaculation was caused by diazepam (1.0 and 2.0 mg/kg). The increase in escape latency induced by ejaculation was prevented by the benzodiazepine antagonist, flumazenil (20.0 mg/kg). Conversely, the opiate antagonist, naloxone (1.0 mg/kg), was unable to reverse the increase in escape latency provoked by ejaculation. Morphine (0.5 mg/kg) did not elicit an increase in the escape latency behaviour. All data support the idea that the hot plate test might reveal false data respect a putative algesic change after ejaculation in male rats.es_ES
dc.subject.kwNocicepciónes_ES
dc.subject.kwRata machoes_ES
dc.subject.kwComportamiento sexuales_ES
dc.subject.kwAnsiedades_ES
dc.subject.kwPlaca calientees_ES
dc.subject.kwDiazepames_ES
dc.subject.kwFlumazeniles_ES
dc.subject.kwMorfinaes_ES
dc.subject.kwNaloxonaes_ES
dc.subject.koNociceptiones_ES
dc.subject.koMale rates_ES
dc.subject.koSexual behaviores_ES
dc.subject.koAnxietyes_ES
dc.subject.koHot platees_ES
dc.subject.koDiazepames_ES
dc.subject.koFlumazeniles_ES
dc.subject.koMorphinees_ES
dc.subject.koNaloxonees_ES


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