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Quantitative analysis of concentration-response curves for precipitated abstinence responses in the opiate-dependent guinea pig ileum

dc.creatorCruz, S.L.
dc.creatorSalazar, L.A.
dc.creatorFernández-Guasti, A.
dc.creatorVillarreal, J.E.
dc.date.accessioned2017-06-29T04:17:07Z
dc.date.available2017-06-29T04:17:07Z
dc.date.issued1993es_ES
dc.identifier173es_ES
dc.identifier.issn0022-3565es_ES
dc.identifier.urihttp://jpet.aspetjournals.org/content/265/3/1519.full.pdf+htmles_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4867
dc.language.isoenges_ES
dc.relation265 (3) 1519-1556 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleQuantitative analysis of concentration-response curves for precipitated abstinence responses in the opiate-dependent guinea pig ileumes_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Terapéutica Experimental, CINVESTAV, IPN, México, D.F.es_ES
dc.relation.jnabreviadoJ PHARMACOL EXP THERes_ES
dc.relation.journalThe Journal of Pharmacology and Experimental Therapeuticses_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published1993es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1521-0103es_ES
dc.description.monthJunes_ES
dc.description.abstractotrodiomaOur group has introduced a theoretical model of drug-receptor-effector interactions that can account for most of the kinetic aspects of opiate dependence and abstinence. The present study analyzes the experimental concentration-response curves for precipitated abstinence responses in the isolated guinea pig ileum and compares them with the curves generated by the mathematical model. Two experimental series were included: in the first, the effects of morphine exposure time on dependence development were analyzed; in the second, the effects of morphine concentration were studied. The results show that both the exposure time and morphine concentration determine the magnitude of precipitated abstinence responses. Dependence can be detected after exposure times to opiates as short as 7.5 min. The concentration-response curves for abstinence responses precipitated by naloxone in ilea exposed to morphine for different periods showed: 1) an initial increase in Emax; 2) a parallel shift to the left in the position of the abstinence curves as dependence develops; and 3) an asymptotic limit to the displacement on the left. The results presented here fit well with theoretical predictions. Practical and theoretical implications are discussed.es_ES
dc.subject.koAnimalses_ES
dc.subject.koDose-Response Relationship, Druges_ES
dc.subject.koGuinea Pigses_ES
dc.subject.koIleum-Drug effectses_ES
dc.subject.koIleum-Physiopathologyes_ES
dc.subject.koKineticses_ES
dc.subject.koMalees_ES
dc.subject.koMorphinees_ES
dc.subject.koNaloxonees_ES
dc.subject.koSubstance Withdrawal Syndromees_ES
dc.subject.koSubstance-Related Disorderses_ES
dc.subject.koTime Factorses_ES
dc.subject.koNaloxonees_ES
dc.subject.koMorphinees_ES


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