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Characterization of mu opioid receptor binding during amygdala kindling in rats and effects of chronic naloxone pretreatment: an autoradiographic study

dc.creatorRocha, L.
dc.creatorAckermann, R.F.
dc.creatorNassir, Y.
dc.creatorChugani, H.T.
dc.creatorEngel Jr., J.
dc.date.accessioned2017-06-29T04:16:29Z
dc.date.available2017-06-29T04:16:29Z
dc.date.issued1993es_ES
dc.identifier156es_ES
dc.identifier.issn0920-1211es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4850
dc.identifier.urihttps://doi.org/10.1016/0920-1211(93)90044-8es_ES
dc.language.isoenges_ES
dc.relation14 (3) 195-208 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleCharacterization of mu opioid receptor binding during amygdala kindling in rats and effects of chronic naloxone pretreatment: an autoradiographic studyes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartments of aNeurology, UCLA, Los Angeles. CA, USA and Instituto Mexicano de Psiquiatría, México DF, Méxicoes_ES
dc.relation.jnabreviadoEPILEPSY RESes_ES
dc.relation.journalEpilepsy Researches_ES
dc.identifier.placeAmsterdam, Holandaes_ES
dc.date.published1993es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.description.monthMares_ES
dc.description.abstractotrodiomaUsing in vitro autoradiography, mu receptor binding in rat brain was characterized at different amygdala kindling stages and in amygdaloid kindled animals pretreated chronically with naloxone. Male Sprague-Dawley rats implanted with bipolar electrodes in the right amygdala received one of the following pretreatments S.C. for 14 days via osmotic minipumps: normal saline solution, 0.5 PI/h, or naloxone HCI, 75 pg/h. Two days after treatments were accomplished animals were stimulated daily. Our data showed different patterns of mu receptor binding during the normal kindling process: during stage II-III, pronounced binding increase was detected in cingulate, temporal and entorhinal cortices, anterior amygdala, caudate putamen, thalamic nuclei, ventrolateral and dorsolateral portions of central gray, substantia nigra pars compacta and pars reticulata. Twenty-four hours after the last stage V kindled seizure, enhanced binding was observed in cingulate and frontoparietal cortices, anterior amygdala, caudate putamen and ventromedial thalamic nucleus. Twenty-eight days after the last stage V kindled seizure, binding augmentation was noticed in cingulate and frontoparietal cortices, whereas decreased binding was detected in amygdala complex, substantia nigra pars reticulata, piriform, perirhinal, parietal, temporal and entorhinal cortices. Mu receptor binding in kindled rats chronically pretreated with naloxone was significantly higher in several structures when compared with control and normal kindled groups. Our data indicate different regional selective patterns of mu receptor binding during amygdala kindling which may depend on epileptogenesis and long-term changes induced by this process. In addition, even higher mu receptor binding results from chronic naloxone administration prior to kindling.es_ES
dc.subject.kwDespertares_ES
dc.subject.kwReceptores Mues_ES
dc.subject.kwOpioideses_ES
dc.subject.kwNaloxonaes_ES
dc.subject.koKindlinges_ES
dc.subject.koMu receptorses_ES
dc.subject.koOpioidses_ES
dc.subject.koNaloxonees_ES


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