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Benzodiazepine receptor binding following chronic treatment with naloxone, morphine and Met-enkephalin in normal rats

dc.creatorRocha, L.
dc.creatorTatsukawa, K.
dc.creatorChugani, H.T.
dc.creatorEngel Jr., J.
dc.date.accessioned2017-06-29T04:16:22Z
dc.date.available2017-06-29T04:16:22Z
dc.date.issued1993es_ES
dc.identifier153es_ES
dc.identifier.issn0006-8993es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4847
dc.identifier.urihttps://doi.org/10.1016/0006-8993(93)91668-Ies_ES
dc.language.isoenges_ES
dc.relation612 (1-2) 247-252 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleBenzodiazepine receptor binding following chronic treatment with naloxone, morphine and Met-enkephalin in normal ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartments of a Neurology, UCLA, Los Angeles, CA (USA), Instituto Mexicano de Psiquiatría, División de Neurociencias, México, D.F. (México)es_ES
dc.relation.jnabreviadoBRAIN RESes_ES
dc.relation.journalBrain researches_ES
dc.identifier.placeAmsterdam, Holandaes_ES
dc.date.published1993es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaThe effects of chronic administration of naloxone, morphine and met-enkephalin on benzodiazepine (BDZ) receptor binding in rat brain were determined 2 and 50 days after treatments were accomplished. Two days after naloxone treatment (75/xg/h s.c. for 14 days), enhanced BDZ receptor binding was observed in cingulate, frontal, piriform, entorhinal and sensorimotor cortices; amygdala complex, hippocampus, substantia nigra and central gray. Two days after morphine treatment (20 mg/kg i,p. daily for 6 days), increased BDZ receptor binding was detected in cingulate, frontal, piriform, entorhinal and sensorimotor cortices; amygdala complex, hippocampus and substantia nigra. Two days after met-enkephalin treatment (10 /xg/h i.c.v, for 6 days) enhanced BDZ receptor binding was shown only in sensorimotor cortex. No significant changes were observed 50 days after the treatments were completed. These data indicate an important interaction between GABAergic and opioid peptide systems.es_ES
dc.subject.kwReceptor de benzodiazepinases_ES
dc.subject.kwÁcido gammaaminobutíricoes_ES
dc.subject.kwNaloxonaes_ES
dc.subject.kwMorfinaes_ES
dc.subject.kwMet-encefalinaes_ES
dc.subject.koBenzodiazepine receptores_ES
dc.subject.koGammay-Aminobutyric acides_ES
dc.subject.koNaloxonees_ES
dc.subject.koMorphinees_ES
dc.subject.koMet-enkephalines_ES


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