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Species differences in the mechanism through which the serotonergic agonists indorenate and ipsapirone produce their anxiolytic action

dc.creatorFernández-Guasti, A.
dc.creatorHong, E.es_ES
dc.creatorLópez-Rubalcava, C.es_ES
dc.date.accessioned2017-06-29T04:15:57Z
dc.date.available2017-06-29T04:15:57Z
dc.date.issued1992es_ES
dc.identifier140es_ES
dc.identifier.issn0033-3158es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4834
dc.identifier.urihttps://doi.org/10.1007/BF02244966es_ES
dc.language.isoenges_ES
dc.relation107 (1) 61-68 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleSpecies differences in the mechanism through which the serotonergic agonists indorenate and ipsapirone produce their anxiolytic actiones_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Farmacología y Toxicología, CINVESTAV, México D.F.es_ES
dc.relation.jnabreviadoPSYCHOPHARMACOLOGYes_ES
dc.relation.journalPsychopharmacologyes_ES
dc.identifier.placeAlemaniaes_ES
dc.date.published1992es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1432-2072es_ES
dc.identifier.doi10.1007/BF02244966es_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaThe effect of three anxiolytic drugs, indorenate, ipsapirone and diazepam, on the burying behaviour of rats and mice was studied. All three drugs induced a reduction in burying behaviour interpreted as a reduction in anxiety. However, a species difference in the diazepam sensitivity was found: rats showed a clear effect after 1.0 mg-kg while already at 0.25 mg-kg an action was observed in mice. The serotonergic anxiolytics produced similar responses at similar doses (2.5–5.0 mg-kg) in both species. The serotonergic antagonists, pindolol (3.1 mg-kg), alprenolol (5.0 mg-kg) and methiotepin (0.31 mg-kg), induced a slight reduction in the time spent burying but effectively counteracted the anxiolytic action of the serotonergic agonists in mice but not in rats. By contrast, in rats, the beta blocker, practolol (0.5 mg-kg), was the only drug effective in preventing the anxiolytic actions of ipsapirone. The combined treatment of indorenate and methiotepin resulted in an impairment of motor coordination and ambulatory behaviour in both species studied, thereby suggesting that the lack of effect of such combination was mediated by altering the motor behaviour. Finally, the reduction in ambulatory behaviour in mice produced by ipsapirone was effectively prevented by the antagonists methiotepin, pindolol and alprenolol indicating the involvement of a serotonergic receptor in this effect. From these results it is concluded that a different mechanism underlies the anxiolytic actions of indorenate and ipsapirone in mice and ratses_ES
dc.subject.ko5-Methoxytryptamine-Analogs & derivativeses_ES
dc.subject.ko5-Methoxytryptamine-Pharmacologyes_ES
dc.subject.koAlprenolol-Pharmacologyes_ES
dc.subject.koAnalysis of Variancees_ES
dc.subject.koAnimalses_ES
dc.subject.koAnti-Anxiety Agents-Pharmacologyes_ES
dc.subject.koBehavior, Animal-Drug effectses_ES
dc.subject.koDiazepam-Pharmacologyes_ES
dc.subject.koMalees_ES
dc.subject.koMethiothepin-Pharmacologyes_ES
dc.subject.koMicees_ES
dc.subject.koPindolol-Pharmacologyes_ES
dc.subject.koPyrimidines-Pharmacologyes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Inbred Strainses_ES
dc.subject.koReceptors, Serotonin-Drug effectses_ES
dc.subject.koSpecies Specificityes_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.koPyrimidineses_ES
dc.subject.koReceptors, Serotonines_ES
dc.subject.koPindololes_ES
dc.subject.koAlprenololes_ES
dc.subject.koMethiothepines_ES
dc.subject.koDiazepames_ES
dc.subject.ko5-Methoxytryptaminees_ES
dc.subject.koIpsapironees_ES
dc.subject.koIndorenatees_ES


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