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Further evidence showing that the inhibitory action of serotonin on rat masculine sexual behavior is mediated after the stimulation of 5-HT1B receptors

dc.creatorFernández-Guasti, A.
dc.creatorRodríguez-Manzo, G.
dc.date.accessioned2017-06-29T04:15:52Z
dc.date.available2017-06-29T04:15:52Z
dc.date.issued1992es_ES
dc.identifier138es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/0091-3057(92)90150-Ees_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4832
dc.language.isoenges_ES
dc.relation42 (3) 529-533 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleFurther evidence showing that the inhibitory action of serotonin on rat masculine sexual behavior is mediated after the stimulation of 5-HT1B receptorses_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV, Instituto Mexicano de Psiquiatría, México D.F., Méxicoes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology Biochemistry and Behaviores_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published1992es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/0091-3057(92)90150-Ees_ES
dc.description.monthJules_ES
dc.description.abstractotrodiomaTo explore whether the inhibitory actions of endogenous serotonin on rat male sexual behavior were mediated via the stimulation of the 5-hydroxytryptamine1A (5-HT1A) or 5-HT1B receptor subtypes, two series of studies were undertaken. In the first series, an attempt to block the inhibitory actions of threshold doses of the serotonin precursor 5-hydroxytryptophan (5-HTP, 50 mg-kg) by administering the _-5HT antagonist alprenolol (5.0 mg-kg) and the selective _-blocker practolol (0.5 mg-kg) was made. Both antagonists effectively prevented, at least partially, the inhibitory actions of 5-HTP. In the second series, a possible synergistic effect of a subthreshold dose 5-HTP (12.5 mg-kg) with low doses of the selective 5-HT1B agonist 1-(m-trifluoro-methylphenyl)piperazine (TFMPP, 0.125 mg-kg) or the selective 5-HT1Aagonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT, 0.0625 mg-kg) was investigated. A clear synergistic inhibitory effect of 5-HTP with TFMPP was observed. All data are interpreted based upon the hypothesis suggesting a physiological inhibitory role of the 5-HT1B receptor subtype on male rat sexual behaviores_ES
dc.subject.ko5-Hydroxytryptophan-Pharmacologyes_ES
dc.subject.ko8-Hydroxy-2-(di-n-propylamino)tetralin-Pharmacologyes_ES
dc.subject.koAlprenolol-Pharmacologyes_ES
dc.subject.koAnimalses_ES
dc.subject.koEjaculation-Drug effectses_ES
dc.subject.koMalees_ES
dc.subject.koPiperazines-Pharmacologyes_ES
dc.subject.koPractolol-Pharmacologyes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Wistares_ES
dc.subject.koReceptors, Serotonin-Drug effectses_ES
dc.subject.koSerotonin-Pharmacologyes_ES
dc.subject.koSexual Behavior, Animal-Drug effectses_ES
dc.subject.koPiperazineses_ES
dc.subject.koReceptors, Serotonines_ES
dc.subject.koAlprenololes_ES
dc.subject.ko1-(3-trifluoromethylphenyl)piperazinees_ES
dc.subject.koSerotonines_ES
dc.subject.ko5-Hydroxytryptophanes_ES
dc.subject.koPractololes_ES
dc.subject.ko8-Hydroxy-2-(di-n-propylamino)tetralines_ES


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