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Stimulation of 5-HT1A and 5-HT1B receptors in brain regions and its effects on male rat sexual behaviour

dc.creatorFernández-Guasti, Alonso
dc.creatorEscalante, Ana Luisa
dc.creatorAhlenius, Sven
dc.creatorHillegaart, Viveka
dc.creatorLarsson, Knut
dc.date.accessioned2017-06-29T04:15:44Z
dc.date.available2017-06-29T04:15:44Z
dc.date.issued1992es_ES
dc.identifier134es_ES
dc.identifier.issn0014-2999es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/0014-2999(92)90662-Nes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4828
dc.language.isoenges_ES
dc.relation210 (2) 121-129 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleStimulation of 5-HT1A and 5-HT1B receptors in brain regions and its effects on male rat sexual behavioures_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacología, CINVESTAV, D.F., Méxicoes_ES
dc.relation.jnabreviadoEUR J PHARMACOLes_ES
dc.relation.journalEuropean Journal of Pharmacologyes_ES
dc.identifier.placePaíses Bajoses_ES
dc.date.published1992es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1879-0712es_ES
dc.identifier.doi10.1016/0014-2999(92)90662-Nes_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaIn the present series of experiments we compared the effect of injecting serotonin (40 _g-cannula), the 5-HT1A agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (5.0 _g-cannula), and the 5-HT1B-C agonist, trifluoromethyl-phenyl-piperazine (TFMPP) (1.0 _g-cannula), into the preoptic area, the nucleus accumbens and the nucleus raphe dorsalis. The dose injected was selected on the basis of dose-response curves. Injection of serotonin and TFMPP into the medial preoptic area and nucleus accumbens resulted in an inhibition of male sexual behaviour, as evidenced by an increase in the number of mounts and a prolongation of the ejaculation latency. Injection of 8-OH-DPAT into these brain areas facilitated copulatory behaviour as evidenced by a reduction in the number of mounts, intromissions and ejaculation latency. Administration of these compounds into the nucleus raphe dorsalis produced no effect, except for a prolongation of the intromission latency after serotonin. These results would suggest that at least some of the 5-HT1A receptors involved in the facilitation of male sexual behaviour are located postsynaptically in limbic brain areas that regulate male sexual behaviour. On the basis of the similarities between the inhibitory effects of serotonin and TFMPP, the present results further support the idea that endogenous serotonin acts via the stimulation of 5-HT1B receptors to inhibit male sexual behavioures_ES
dc.subject.ko8-Hydroxy-2-(di-n-propylamino)tetralines_ES
dc.subject.koAnimalses_ES
dc.subject.koBrain-Drug effectses_ES
dc.subject.koCatheterizationes_ES
dc.subject.koDose-Response Relationship, Druges_ES
dc.subject.koMalees_ES
dc.subject.koPiperazines-Pharmacologyes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Inbred Strainses_ES
dc.subject.koReceptors, Serotonines_ES
dc.subject.koSerotonines_ES
dc.subject.koSexual Behavior, Animales_ES
dc.subject.koTetrahydronaphthaleneses_ES
dc.subject.ko1-(3-trifluoromethylphenyl)piperazinees_ES
dc.subject.koSerotonines_ES
dc.subject.ko8-Hydroxy-2-(di-n-propylamino)tetralines_ES


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