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Differential role of serotonin and noradrenaline on anxiety reduction after ejaculation in the rat

dc.creatorSaldívar, A.
dc.creatorRíos, C.
dc.creatorFernández-Guasti, A.
dc.date.accessioned2017-06-29T04:15:26Z
dc.date.available2017-06-29T04:15:26Z
dc.date.issued1991es_ES
dc.identifier125es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/0091-3057(91)90246-Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4819
dc.language.isoenges_ES
dc.relation38 (4) 807-312 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleDifferential role of serotonin and noradrenaline on anxiety reduction after ejaculation in the rates_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacología y Toxicología CINVESTAV, División de Investigaciones en Neurociencias, Instituto Mexicano de Psiquiatría, México D.F.es_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology Biochemistry and Behaviores_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published1991es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/0091-3057(91)90246-Xes_ES
dc.description.monthAbres_ES
dc.description.abstractotrodiomaAs previously reported, a reduction in anxiety after ejaculation was observed. In a previous report it was demonstrated that the GABA-benzodiazepine system is involved in the mediation of this reduction in anxiety. The anxiety levels were measured using a defensive burying model. This work was performed to elucidate the serotonin and noradrenaline participation in the mediation of this phenomenon. Two experiments were made. In the first experiment the serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT, 10 _g-10 _l) was intracerebroventricularly injected. Five days after its administration the behavioral tests were performed. In the second experiment, the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4, 50 mg-kg _ 2) was IP administered. The neurochemical data reveal a drastic reduction in various brain areas respective monoamine levels after these treatments. The lesion produced by 5,7-DHT was able to reverse the reduction in anxiety in copulating males, but produced no changes in noncopulating animals. This finding supports the idea that the serotonergic system in involved in the reduction of anxiety observed after ejaculation. The results of the DSP4 experiment suggest that there is not a direct participation of the noradrenergic system in the anxiety reduction observed after ejaculation.es_ES
dc.subject.ko5,7-Dihydroxytryptamine-Pharmacologyes_ES
dc.subject.koAnimalses_ES
dc.subject.koAnxiety-Physiopathologyes_ES
dc.subject.koBenzylamines-Pharmacologyes_ES
dc.subject.koEjaculation-Physiologyes_ES
dc.subject.koMalees_ES
dc.subject.koNeurotoxins-Pharmacologyes_ES
dc.subject.koNorepinephrine-Physiologyes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Inbred Strainses_ES
dc.subject.koSerotonin-Physiologyes_ES
dc.subject.koBenzylamineses_ES
dc.subject.koNeurotoxinses_ES
dc.subject.ko5,7-Dihydroxytryptaminees_ES
dc.subject.koSerotonines_ES
dc.subject.koNorepinephrinees_ES
dc.subject.koDSP 4es_ES


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