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Role of presynaptic serotonergic receptors on the mechanism of action of 5-HT1A and 5-HT1B agonists on masculine sexual behaviour: physiological and pharmacological implications

dc.creatorFernández-Guasti, A.
dc.creatorEscalante, A.
dc.date.accessioned2017-06-29T04:15:23Z
dc.date.available2017-06-29T04:15:23Z
dc.date.issued1991es_ES
dc.identifier123es_ES
dc.identifier.issn0300-9564es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4817
dc.identifier.urihttps://doi.org/10.1007/BF01244702es_ES
dc.language.isoenges_ES
dc.relation85 (2) 95-107 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleRole of presynaptic serotonergic receptors on the mechanism of action of 5-HT1A and 5-HT1B agonists on masculine sexual behaviour: physiological and pharmacological implicationses_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacologia y Toxicologia, CINVESTAV and División de Investigaciones en Neurociencias IMP, México D. F., México.es_ES
dc.relation.jnabreviadoJ NEURAL TRANSM GEN SECTes_ES
dc.relation.journalJournal of Neural Transmission. General Sectiones_ES
dc.identifier.placeAustriaes_ES
dc.date.published1991es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.description.abstractotrodiomaIn order to establish whether the 5-HT1A or the 5HT1B agonists, 8-OH-DPAT or TFMPP, produce their facilitatory or inhibitory actions on masculine sexual behaviour via a mechanism involving: (a) the serotonin synthesis or release; (b) the stimulation of presynaptic receptors, or (c) the stimulation of somatodendritic receptors, three series of experiments were performed. The administration of the serotonin synthesis inhibitor, p-chlorophenylalanine (p-CPA, 300 mg-kg x 3 days), facilitated sexual behaviour but does not interfere neither with the inhibitory nor with the facilitatory effects of TFMPP (0.5 mg-kg) or 8-OH-DPAT (0.5 mg-kg), respectively. The icv or the intraraphé administration of the serotonergic neurotoxin, 5,7-dihydroxytryptamine (5,7-DHT), slightly stimulated masculine sexual behaviour and produced a decrease in serotonin and its metabolite levels. In lesioned animals TFMPP (0.5 mg-kg) resulted in an inhibitory effect reflected as a prolongation of the ejaculation latency. The inhibitory effect of this drug on mounting behaviour was not observed in 5,7-DHT treated rats. In lesioned animals 8-OH-DPAT (0.5 mg-kg) produced the same facilitatory effect. Present data indicate that serotonergic postsynaptic receptors mediate both the inhibitory and the facilitatory actions of TFMPP or 8-OH-DPAT in copulation. All data further support the idea that endogenous serotonin acts via the stimulation of 5-HT1B receptors to induce its inhibitory effects on masculine sexual behaviour.es_ES
dc.subject.ko5,7-Dihydroxytryptamine-Pharmacologyes_ES
dc.subject.ko8-Hydroxy-2-(di-n-propylamino)tetralines_ES
dc.subject.koAnimalses_ES
dc.subject.koCopulation-Drug effectses_ES
dc.subject.koFenclonine-Pharmacologyes_ES
dc.subject.koMalees_ES
dc.subject.koPiperazines-Pharmacologyes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Inbred Strainses_ES
dc.subject.koReceptors, Serotonin-Drug effectses_ES
dc.subject.koReceptors, Serotonin-Physiologyes_ES
dc.subject.koSexual Behavior, Animal-Drug effectses_ES
dc.subject.koTetrahydronaphthalenes-Pharmacologyes_ES
dc.subject.koPiperazineses_ES
dc.subject.koReceptors, Serotonines_ES
dc.subject.koTetrahydronaphthaleneses_ES
dc.subject.ko1-(3-trifluoromethylphenyl)piperazinees_ES
dc.subject.ko5,7-Dihydroxytryptaminees_ES
dc.subject.koFencloninees_ES
dc.subject.ko8-Hydroxy-2-(di-n-propylamino)tetralines_ES


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