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Effects of chronic naloxone pretreatment on amygdaloid kindling in rats

dc.creatorRocha, Luisa
dc.creatorEngel Jr., Jerome
dc.creatorAckermann, Robert F.
dc.date.accessioned2017-06-29T04:15:14Z
dc.date.available2017-06-29T04:15:14Z
dc.date.issued1991es_ES
dc.identifier117es_ES
dc.identifier.issn0920-1211es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4812
dc.identifier.urihttps://doi.org/10.1016/0920-1211(91)90002-Wes_ES
dc.language.isoenges_ES
dc.relation10, 103-110 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleEffects of chronic naloxone pretreatment on amygdaloid kindling in ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartments of Neurology, UCLA, Los Angeles, CA (U.S.A.), Instituto Mexicano de Psiquiatría and Departamento de Farmacología, Fac. de Medicina, UNAM (México)es_ES
dc.relation.jnabreviadoEPILEPSY RESes_ES
dc.relation.journalEpilepsy Researches_ES
dc.identifier.placeAmsterdam, Holandaes_ES
dc.date.published1991es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.description.monthNov-Dices_ES
dc.description.abstractotrodiomaEffects of chronic naloxone pretreatment (75 or 270/~gha for 14 days) on the development of amygdaloid kindling in rats were evaluated. The acquisition of seizure activity was modified in the naloxone pretreated animals, depending on the nucleus stimulated: facilitation of stages IV and V occurred in 37%, variability of electrographic and behavioral responses to electrical stimulation during the kindling development in 33%, and facilitation of stages IV and V followed by long periods of seizure suppression in 29%. Enhancement of postictal seizure suppession during a recycling paradigm was observed in all the naloxone pretreated rats. It was concluded that the chronic administration of naloxone (known to induce opioid binding upregulation and supersensitivity), in association with the enduring changes in opioid mechanisms provoked by kindled seizures, were responsible for the facilitation and suppression of epileptic activity. These findings support bidirectional modulatory effects of opioid peptides on epileptic seizures as well as the view that epileptic seizures can induce enduring alterations in opioid mechanisms.es_ES
dc.subject.kwAmígdalaes_ES
dc.subject.kwDespertares_ES
dc.subject.kwNaloxonaes_ES
dc.subject.kwReceptores opioideses_ES
dc.subject.kwLipoproteícoses_ES
dc.subject.koAmygdalaes_ES
dc.subject.koKindlinges_ES
dc.subject.koNaloxonees_ES
dc.subject.koOpioid receptorses_ES
dc.subject.koUpregulationes_ES


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