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Characterization of indorenate effects on brain monoamine metabolism

dc.creatorBenítez-King, Gloria
dc.creatorAntón-Tay, Fernando
dc.date.accessioned2017-06-29T04:15:13Z
dc.date.available2017-06-29T04:15:13Z
dc.date.issued1991es_ES
dc.identifier116es_ES
dc.identifier.issn0272-4391es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4811
dc.language.isoenges_ES
dc.relation23 (4) 325-331 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleCharacterization of indorenate effects on brain monoamine metabolismes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartmento de Neurofarmacología, Instituto Mexicano de Psiquiatría Mexicoes_ES
dc.relation.jnabreviadoDRUG DEV RESes_ES
dc.relation.journalDrug Development Researches_ES
dc.identifier.placeNew Yorkes_ES
dc.date.published1991es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.doi10.1002/ddr.430230405es_ES
dc.description.abstractotrodiomaThe effect of indorenate, a central antihypertensive agent, on the catecholamine and indolamine metabolism was studied in the rat brain. Acute administration of 10 mg/kg of indorenate causes an increase in 5-HT concentrations and a decrease on its metabolite 5-hydroxyindolacetic acid (5-HIAA) in the brain stem, cerebral cortex, hypothalamus, and striatum. Maximal effects were observed between 1.5 and 3 hr after indorenate administration. Additionally, a significant decrease in homovanilic acid (HVA) and 3,4-dihydroxyphenylacetic (DOPAC) concentrations was noted after 1.5 hr of a 10 mg/kg indorenate injection. Modification of both catecholamine and indolamine metabolites was dose related. Control values were recovered 24 hr after indorenate administration. Activity of monoamine oxidase present in crude homogenates obtained from the cerebral cortex, brain stem, hypothalamus, and striatum was not affected by indorenate. The present results suggest that indorenate acts as an agonist at serotonin receptors in the central nervous system (CNS).es_ES
dc.subject.kwSerotoninaes_ES
dc.subject.kwDopaminaes_ES
dc.subject.kwMecanismo de acciónes_ES
dc.subject.kwSistema Nervioso Centrales_ES
dc.subject.koSerotonines_ES
dc.subject.koDopaminees_ES
dc.subject.koMechanism of actiones_ES
dc.subject.koCentral nervous systemes_ES


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