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Melatonin modifies calmodulin cell levels in MDCK and N1E-115 cell lines and inhibits phosphodiesterase activity in vitro

dc.creatorBenítez-King, G.
dc.creatorHuerto-Delgadillo, L.
dc.creatorAntón-Tay, F.
dc.date.accessioned2017-06-29T04:15:11Z
dc.date.available2017-06-29T04:15:11Z
dc.date.issued1991es_ES
dc.identifier115es_ES
dc.identifier.issn0006-8993es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4810
dc.identifier.urihttps://doi.org/10.1016/0006-8993(91)90146-Mes_ES
dc.language.isoenges_ES
dc.relation557 (1-2) 289-292 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleMelatonin modifies calmodulin cell levels in MDCK and N1E-115 cell lines and inhibits phosphodiesterase activity in vitroes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Neurofarmacología, Instituto Mexicano de Psiquiatría, Méxicoes_ES
dc.relation.jnabreviadoBRAIN RESes_ES
dc.relation.journalBrain Researches_ES
dc.identifier.placeNetherlandses_ES
dc.date.published1991es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.description.monthAgoes_ES
dc.description.abstractotrodiomaThe interaction between melatonin and calmodulin was explored. Calmodulin cell levels in MDCK and N1E-115 cells cultured with 10(-9) M melatonin were increased after 3 days but decreased after 6 days. Melatonin inhibited calmodulin-dependent phosphodiesterase and when either melatonin or [3H]melatonin was preincubated with calmodulin and separated by electrophoresis, comigration of calmodulin with the radioactivity as well as modification of the Ca2+ calmodulin shift were observed. The results point out that one of the mechanisms of action of melatonin is a calmodulin-melatonin interactiones_ES


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