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Anxiolytics reverse the acceleration of ejaculation resulting from enforced intercopulatory intervals in rats

dc.creatorFernández-Guasti, Alonso
dc.creatorRoldán-Roldán, Gabriel
dc.creatorLarsson, Knut
dc.date.accessioned2017-06-29T04:15:08Z
dc.date.available2017-06-29T04:15:08Z
dc.date.issued1991
dc.identifier113es_ES
dc.identifier.issn0735-7044es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4808
dc.identifier.urihttps://doi.org/10.1037/0735-7044.105.2.230es_ES
dc.language.isoenges_ES
dc.relation105 (2) 230-240 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAnxiolytics reverse the acceleration of ejaculation resulting from enforced intercopulatory intervals in ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationCentro de Investigación y Estudios Avanzados, Instituto Politécnico Nacional and Instituto Méxicano de Psiquiatría Federal District of Mexico.es_ES
dc.relation.jnabreviadoBEHAV NEUROSCIes_ES
dc.relation.journalBehavioral Neurosciencees_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published1991es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1939-0084es_ES
dc.description.monthAbres_ES
dc.description.abstractotrodiomaThe enforced interval of copulation (EIC) consists of the artificial prolongation of the interintromission interval, induces a reduction in the number of intromissions preceding ejaculation, and is accompanied by an anxiety like behavioral repertoire. The administration of the benzodiazepine anxiolytics diazepam, chlordiazepoxide, flurazepam, and flunitrazepam produced a dose-dependent inhibition of the EIC effect with a concomitant increase in mounting. These actions were blocked by the central benzodiazepine antagonist Ro 15-1788. The anxiogenic agent beta-carboline Zk 39106 had no effect. Treatment with pentobarbital also produced a blockade of the reduction in the number of intromissions during EIC, whereas muscimol and bicuculline lacked this effect. The serotonergic anxiolytic buspirone reversed the facilitatory action induced by EIC; however, two putative serotonergic antianxiety agents, 8-OH-DPAT and ipsapirone, did not modify or potentiate it, respectively. Finally, the nonanxiolytic serotonergic compounds 5-hydroxytryptophan and TFMPP drastically increased the number of mounts but did not antagonize the reduction of intromissions produced by EIC. These results suggest that an increase in the anxiety levels may be responsible for the excitatory action of EIC on sexual behaviores_ES
dc.subject.koAdrenergic alpha-Agonists-Pharmacologyes_ES
dc.subject.koAnimalses_ES
dc.subject.koAnti-Anxietyes_ES
dc.subject.koAgents-Pharmacologyes_ES
dc.subject.koArousal-Drug effectses_ES
dc.subject.koBenzodiazepineses_ES
dc.subject.koBicuculline-Pharmacologyes_ES
dc.subject.koBuspirone-Pharmacologyes_ES
dc.subject.koDose-Responsees_ES
dc.subject.koRelationship, Druges_ES
dc.subject.koEjaculation-Drug effectses_ES
dc.subject.koMalees_ES
dc.subject.koPiperidines-Pharmacologyes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Inbred Strainses_ES
dc.subject.koReaction Time-Drug effectses_ES
dc.subject.koReceptors, GABA-A-Drug effectses_ES
dc.subject.koReceptors, Serotonin-Drug effectses_ES
dc.subject.koSexual Behavior, Animal-Drug effectses_ES
dc.subject.koSocial Environmentes_ES
dc.subject.koAdrenergic alpha-Agonistses_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.koPiperidineses_ES
dc.subject.koReceptors, GABA-Aes_ES
dc.subject.koReceptors, Serotonines_ES
dc.subject.koBenzodiazepineses_ES
dc.subject.koBuspironees_ES
dc.subject.koBicucullinees_ES
dc.subject.koZK 33839es_ES


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