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Behavioral effects of fluprazine in lactating hamsters and in their progeny

dc.creatorMendoza, Diana L.
dc.creatorMondragón, Ricardo
dc.creatorMayagoitia, Lilian
dc.creatorRandall, Cristina B.
dc.date.accessioned2017-06-29T04:15:03Z
dc.date.available2017-06-29T04:15:03Z
dc.date.issued1990es_ES
dc.identifier110es_ES
dc.identifier.issn0033-2933es_ES
dc.identifier.urihttps://doi.org/10.1007/BF03399548es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4805es_ES
dc.language.isoenges_ES
dc.relation40 (3) 385-395 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleBehavioral effects of fluprazine in lactating hamsters and in their progenyes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartment of Psychobiology, University of Seville, P.O. Box 3128, 41080 Seville Spaines_ES
dc.relation.jnabreviadoPSYCHOL RECes_ES
dc.relation.journalThe Psychological Recordes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published1990es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.description.abstractotrodiomaThe spontaneous behavior of dams and pups was observed during lactation period, following daily i.p. administration of fluprazine (8 mg-kg-day) to females after parturition. Ethological techniques were applied, scanning every 30 min through 8 hr per day. Chronic treatment with fluprazine hydrochloride (DU 27716) to lactating hamsters, decreased nest building and self-grooming, disrupted pup retrieval, and increased infanticide. other behaviors, such as nursing, exploration, attention, and ingestion were not altered indicating lack of sedative effects. Pups from fluprazine-treated mothers showed a decrease in the activity level, as well as lower mean weight than control infants. This suggests an interference on the mother-infant interactions, and-or fluprazine effects by drug or metabolites transfer via breast milk. Some censorial (olfactory interference) and emotional (stress and fear) factors are considered as possible mechanisms for the behavioral action of fluprazine.es_ES
dc.subject.koExertion of strong inhibitory action on offensive behaviores_ES
dc.subject.koEffect on social interactionses_ES
dc.subject.koMuscle-relaxant effectses_ES


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