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Evidence for the involvement of the 5-HT1A receptor in the anxiolytic action of indorenate and ipsapirone

dc.creatorFernández-Guasti, A.
dc.creatorLópez-Rubalcava, C.
dc.date.accessioned2017-06-29T04:14:51Z
dc.date.available2017-06-29T04:14:51Z
dc.date.issued1990es_ES
dc.identifier103es_ES
dc.identifier.issn0033-3158es_ES
dc.identifier.urihttp://link.springer.com/article/10.1007%2FBF02244053?LI=truees_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4798
dc.language.isoenges_ES
dc.relation101 (3) 354- 358 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleEvidence for the involvement of the 5-HT1A receptor in the anxiolytic action of indorenate and ipsapironees_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV and División de Investigaciones en Neurociencias, Instituto Mexicano de Psiquiatría, México D.F., México.es_ES
dc.relation.jnabreviadoPSYCHOPHARMACOLOGYes_ES
dc.relation.journalPsychopharmacologyes_ES
dc.identifier.placeAlemaniaes_ES
dc.date.published1990es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1432-2072es_ES
dc.identifier.doi10.1007/BF02244053es_ES
dc.description.monthJules_ES
dc.description.abstractotrodiomaThe systemic injection of diazepam (0.5 and 1.0 mg-kg), indorenate (5 and 10 mg-kg) and ipsapirone (2.5 and 5.0 mg-kg) reduced anxiety as tested in an exploratory avoidance model in mice. The injection of pindolol (2.0 mg-kg), alprenolol (5.0 mg-kg) or methiotepin (0.25 mg-kg) effectively prevented the anxiolytic action of indorenate and ipsapirone. The combined treatment of the antagonists with indorenate or ipsapirone did not reduce the motor activity, therefore suggesting that the inhibition of exploratory behaviour, after such combinations, was not mediated through a general motor impairment. Neither diazepam nor indorenate alone modified the motor activity; ipsapirone (5 and 2.5 mg-kg), however, reduced ambulation. This reduction was also prevented by administering pindolol, alprenolol or methiotepin. These observations suggest that the anxiolytic actions of indorenate and ipsapirone are mediated via stimulation of the 5-HT1A like receptor subtypees_ES
dc.subject.ko5-Methoxytryptamine-Analogs & derivativeses_ES
dc.subject.ko5-Methoxytryptamine-Pharmacologyes_ES
dc.subject.koAlprenolol-Pharmacologyes_ES
dc.subject.koAnimalses_ES
dc.subject.koAnti-Anxiety Agents-Pharmacologyes_ES
dc.subject.koAntihypertensivees_ES
dc.subject.koAgents-Pharmacologyes_ES
dc.subject.koDiazepam-Pharmacologyes_ES
dc.subject.koExploratory Behavior-Drug effectses_ES
dc.subject.koMalees_ES
dc.subject.koMethiothepin-Pharmacologyes_ES
dc.subject.koMicees_ES
dc.subject.koMotor Activity-Drug effectses_ES
dc.subject.koPindolol-Pharmacologyes_ES
dc.subject.koPyrimidines-Pharmacologyes_ES
dc.subject.koReceptors, Serotonin-Drug effectses_ES
dc.subject.koSerotonin-Analogs & derivativeses_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.koAntihypertensive Agentses_ES
dc.subject.koPyrimidineses_ES
dc.subject.koReceptors, Serotonines_ES
dc.subject.koPindololes_ES
dc.subject.koAlprenololes_ES
dc.subject.koMethiothepines_ES
dc.subject.koDiazepames_ES
dc.subject.koSerotonines_ES
dc.subject.ko5-Methoxytryptaminees_ES
dc.subject.koIpsapironees_ES
dc.subject.koIndorenatees_ES


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