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Behavioural actions of the serotonergic anxiolytic indorenate

dc.creatorFernández-Guasti, A.
dc.creatorEscalante, A.
dc.creatorHong, E.
dc.creatorAgmo, A.
dc.date.accessioned2017-06-29T04:14:50Z
dc.date.available2017-06-29T04:14:50Z
dc.date.issued1990es_ES
dc.identifier102es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/0091-3057(90)90045-Jes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4797
dc.language.isoenges_ES
dc.relation37 (1) 83-88 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleBehavioural actions of the serotonergic anxiolytic indorenatees_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV, IPN and División de Investigaciones en Neurociencias, Instituto Mexicano de Psiquiatríaes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology Biochemistry and Behaviores_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published1990es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/0091-3057(90)90045-Jes_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaSeveral recent studies have shown that the 5-HT1A agonist indorenate possesses antianxiety properties. In the present study we report on other behavioural actions of this drug. Indorenate (31.6 mg-kg) induced flat body posture, forepaw treading and hind limb abduction, behavioural characteristics of the serotonin syndrome. After indorenate injection these same behaviours were observed in animals pretreated with p-chlorophenylalanine (400 mg-kg _ 3 days), suggesting that the action of this compound is not mediated via serotonin release. The beta-5-HT1 blockers, (_) pindolol (2 mg-kg) or (_) alprenolol (5 mg-kg), did not prevent the actions of indorenate on the serotonin syndrome. Indorenate (10 mg-kg) stimulated the masculine sexual behaviour by reducing the number of intromissions preceding ejaculation. Higher doses (17.8 mg-kg) cause a complete inhibition of sexual behaviour. (_) Pindolol (2 mg-kg) or (_) alprenolol (5 mg-kg) did not antagonize the facilitatory actions of indorenate on male sexual behaviour. A high dose of indorenate (31.6 mg-kg) resulted in an impairment of the motor coordination as tested in a treadmill apparatus. These data reveal that indorenate possesses, in addition to its antianxiety effects, other behavioural characteristics that, however, appear at higher dose levels.es_ES
dc.subject.kwIndorenatees_ES
dc.subject.kwSerotonin syndromees_ES
dc.subject.kwMasculine sexual behaviores_ES
dc.subject.kwMotor coordinationes_ES
dc.subject.kwpCPAes_ES
dc.subject.kw5-HT1 agonistes_ES
dc.subject.ko5-Methoxytryptamine-Analogs & derivativeses_ES
dc.subject.ko5-Methoxytryptamine-Pharmacologyes_ES
dc.subject.koAlprenololes_ES
dc.subject.koAnimalses_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.koBehavior, Animal-Drug effectses_ES
dc.subject.koDose-Response Relationship, Druges_ES
dc.subject.koFencloninees_ES
dc.subject.koMalees_ES
dc.subject.koPindololes_ES
dc.subject.koPsychomotor Performancees_ES
dc.subject.koRatses_ES
dc.subject.koRats, Inbred Strainses_ES
dc.subject.koReceptors, Serotonines_ES
dc.subject.koSexual Behavior, Animales_ES
dc.subject.koSingle-Blind Methodes_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.koReceptors, Serotonines_ES
dc.subject.koPindololes_ES
dc.subject.ko5-Methoxytryptaminees_ES
dc.subject.koFencloninees_ES
dc.subject.koIndorenatees_ES


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