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Pharmacological manipulation of anxiety and male rat sexual behavior

dc.creatorFernández-Guasti, A.
dc.creatorRoldán-Roldán, G.
dc.creatorSaldívar, A.
dc.date.accessioned2017-06-29T04:14:46Z
dc.date.available2017-06-29T04:14:46Z
dc.date.issued1990es_ES
dc.identifier100es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://doi.org/10.1016/0091-3057(90)90237-Ces_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4795
dc.language.isoenges_ES
dc.relation35 (1) 263-267 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAnxiety-Chemically inducedes_ES
dc.subject.meshAnxiety-Drug therapyes_ES
dc.subject.meshAnxiety-Physiopathologyes_ES
dc.subject.meshCarbolines-Antagonists & inhibitorses_ES
dc.subject.meshCarbolines-Pharmacologyes_ES
dc.subject.meshCopulation-Drug effectses_ES
dc.subject.meshDiazepam-Antagonists & inhibitorses_ES
dc.subject.meshDiazepam-Pharmacologyes_ES
dc.subject.meshFlumazeniles_ES
dc.subject.meshMalees_ES
dc.subject.meshPsychomotor Performancees_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Inbred Strainses_ES
dc.subject.meshFG 7142es_ES
dc.titlePharmacological manipulation of anxiety and male rat sexual behaviores_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV, and División de Investigaciones en Neurociencias Instituto Mexicano de Psiquiatría, México D.F., México.es_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology Biochemistry and Behaviores_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published1990es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/0091-3057(90)90237-Ces_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaSeveral anxiolytic-anxiogenic treatments were evaluated on male rat sexual behavior. The anxiolytic drug diazepam (1.0 mg-kg) inhibited copulatory behavior as indicated by an increase in the number of mounts preceding ejaculation, prolongation of the ejaculation latency and the postejaculatory interval. These changes were not accompanied by alterations in motor coordination as tested on a treadmill apparatus. A lower dose of diazepam (0.5 mg-kg) did not affect the sexual behavior. The anxiogenic drug Zk 39106 (2 and 4 mg-kg) facilitated the copulatory behavior by reducing the number of intromissions preceding ejaculation. A higher dose of Zk 39106 (8 mg-kg) inhibited sexual behavior. The selective benzodiazepine antagonist, Ro 15-1788 (5 and 10 mg-kg), did not modify male sexual behavior, but effectively antagonized the effects of Zk 39106 and diazepam. The administration of Zk 39106 (2 mg-kg) reversed the inhibitory action of diazepam (1.0 mg-kg) on copulation; however, diazepam did not prevent the facilitatory effect of Zk 39106. The data are discussed in terms of the possible relationship existing between anxiety and masculine sexual behaviores_ES
dc.subject.kwDiazepames_ES
dc.subject.kwZk 39106es_ES
dc.subject.kwRo 15-1788es_ES
dc.subject.kwAnsiólisises_ES
dc.subject.kwAnsiogénesises_ES
dc.subject.kwComportamiento sexual de la rata machoes_ES
dc.subject.koDiazepames_ES
dc.subject.koZk 39106es_ES
dc.subject.koRo 15-1788es_ES
dc.subject.koAnxiolysises_ES
dc.subject.koAnxiogenesises_ES
dc.subject.koMale rat sexual behaviores_ES


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