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Effects of 1 week administration of two benzodiazepines on the sleep and early daytime performance of normal subjects

dc.creatorJurado, José Luis
dc.creatorFernández-Mas, Rodrigo
dc.creatorFernández-Guardiola, Augusto
dc.date.accessioned2017-06-29T04:14:28Z
dc.date.available2017-06-29T04:14:28Z
dc.date.issued1989es_ES
dc.identifier88es_ES
dc.identifier.issn0033-3158es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4783
dc.identifier.urihttps://doi.org/10.1007/BF00634459es_ES
dc.language.isoenges_ES
dc.relation99 (1) 91-93 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleEffects of 1 week administration of two benzodiazepines on the sleep and early daytime performance of normal subjectses_ES
dc.typearticlees_ES
dc.contributor.affiliationLaboratorio de Sueño, Departamento de Cronobiología, División de Investigaciones en Neurociencias, Instituto Mexicano de Psiquiatría, and Facultad de Psicología, U.N.A.M., Mexico City, Mexicoes_ES
dc.relation.jnabreviadoPSYCHOPHARMACOLOGYes_ES
dc.relation.journalPsychopharmacologyes_ES
dc.identifier.placeAlemaniaes_ES
dc.date.published1989es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1432-2072es_ES
dc.description.monthMares_ES
dc.description.abstractotrodiomaThis study analyzed the effects of 1 week administration of alprazolam (AL; 0.25 mg), lorazepam (LO; 1 mg) and placebo (PL) on sleep as well as their residual effects on attention upon awakening. Under a crossed, doubleblind design, six healthy male volunteer subjects between 19 and 30 years of age were studied. After two habituation sessions and a control session, each substance was given orally, twice a day for 7 days, with a 1-week washout period between administrations. At the end of each administration period, sleep studies were conducted from 2300 to 0700 hours. Evaluation of attention was carried out by means of a simple visuomotor reaction time (RT) task, and a time estimation (TE) task, that started at 0700 hours, lasting 1 h. Neither drug significantly affected any sleep variable. Both benzodiazepines tended to increase RT, but only LO did so significantly at the beginning of the attention test. No significant changes in predictive and failure responses during the RT task were produced by either drug. Also, no significant changes were observed in the TE. Even though only LO produced a significant increase of RT at the selected doses and with 1 week administration, it is suggested that both benzodiazepines could have residual effects on attention.es_ES
dc.subject.koAdultes_ES
dc.subject.koAlprazolam-Pharmacologyes_ES
dc.subject.koAttention-Drug effectses_ES
dc.subject.koHumanses_ES
dc.subject.koLorazepam-Pharmacologyes_ES
dc.subject.koMalees_ES
dc.subject.koReaction Time-Drug effectses_ES
dc.subject.koSleep-Drug effectses_ES
dc.subject.koSubstanceses_ES
dc.subject.koAlprazolames_ES
dc.subject.koLorazepames_ES


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