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Inhibitory action of various 5-HT1B receptor agonists on rat masculine sexual behaviour

dc.creatorFernández-Guasti, A.
dc.creatorEscalante, A.
dc.creatorAgmo, A.
dc.date.accessioned2017-06-29T04:14:25Z
dc.date.available2017-06-29T04:14:25Z
dc.date.issued1989es_ES
dc.identifier86es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/0091-3057(89)90279-7es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4781
dc.language.isoenges_ES
dc.relation34 (4) 811-816 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleInhibitory action of various 5-HT1B receptor agonists on rat masculine sexual behavioures_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacología y Toxicología CINVESTAVes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology Biochemistry and Behaviores_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published1989es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/0091-3057(89)90279-7es_ES
dc.description.monthDices_ES
dc.description.abstractotrodiomaThe systematic administration of the 5-HT1B receptor agonists, RU 24969 (0.25 and 0.5 mg-kg), TFMPP (0.25 and 0.5 mg-kg) and mCPP (0.75 and 1.0 mg-kg) resulted in an inhibition of rat masculine sexual behaviour reflected as a reduction in the proportion of coupling animals. Additionally, the analysis of the sexual behaviour of the animals obtaining ejaculation revealed that RU 24969 and TFMPP administration resulted in an increase in the number of mounts and in a prolongation of the intromission and ejaculation latencies and of the postejaculatory interval. Administration of mCPP increased the number of mounts preceding ejaculation. None of these changes could be attributed to a motor coordination impairment since none of these drugs, at the doses tested, produced changes in a treadmill test. The administration of the 5-HT1A agonist, ipsapirone (2.5, 5 and 10 mg-kg) resulted in a facilitation of the sexual behaviour expressed as a reduction in the number of intromissions preceding ejaculation accompanied by a shortening of the ejaculation latency. Present data show a differential action of 5-HT1A and 5-HT1B receptor subtypes in the control of rat masculine sexual behaviour. The hypothesis that the endogenous serotonin inhibitory action on copulation is mediated via the 5-HT1B receptor subtype is proposed.es_ES
dc.subject.koAnimalses_ES
dc.subject.koIndoles-Pharmacologyes_ES
dc.subject.koMalees_ES
dc.subject.koPiperazines-Pharmacologyes_ES
dc.subject.koPsychomotor Performance-Drug effectses_ES
dc.subject.koPyrimidines-Pharmacologyes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Inbred Strainses_ES
dc.subject.koReceptors, Serotonin-Drug effectses_ES
dc.subject.koSexual Behavior, Animal-Drug effectses_ES


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