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Habituation and dehabituation of the spinal polysynaptic reflex responses: modification by naloxone and opiates and their anatomical correlates

dc.creatorFernández-Guardiola, A.
dc.creatorPellicer, F.
dc.creatorLeón-Olea, M.
dc.creatorAsai, M.
dc.creatorSánchez-Álvarez, M.
dc.date.accessioned2017-06-29T04:14:22Z
dc.date.available2017-06-29T04:14:22Z
dc.date.issued1989es_ES
dc.identifier84es_ES
dc.identifier.issn0143-4179es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/0143-4179(89)90068-1es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4779
dc.language.isoenges_ES
dc.relation14 (2) 115-120 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleHabituation and dehabituation of the spinal polysynaptic reflex responses: modification by naloxone and opiates and their anatomical correlateses_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Mexicano de Psiquiatría, División de Investigaciones en Neurociencias, México.es_ES
dc.relation.jnabreviadoNEUROPEPTIDESes_ES
dc.relation.journalNeuropeptideses_ES
dc.identifier.placeEscociaes_ES
dc.date.published1989es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1532-2785es_ES
dc.identifier.doi10.1016/0143-4179(89)90068-1es_ES
dc.description.monthAgo-Sepes_ES
dc.description.abstractotrodiomaThe sustained inhibitory action of spinal endorphins could be responsible for the habituation of polysynaptic responses in the spinal cord. To test this hypothesis, acute spinalized unanesthetized cats (decerebrated and curarized) were used. Sural nerve electrical stimulation (0.2 Hz) was provided and a progressive decrease in the reflex response was found. Conversely, the field potential (lamina V) progressively increased during stimulation, reaching its maximum amplitude when ventral root response showed maximum habituation. The administration of naloxone (0.8-10.0 mg-kg) produced dehabituation or prevented habituation. The immunohistological results showed leu-enkephalin-like immunoreactive dot-like structures in close proximity to neurons of laminae VII, VIII and IX in the lumbo-sacral segment of the spinal cord. Our results suggest an involvement of opioid peptides in the habituation processes_ES
dc.subject.koAnimalses_ES
dc.subject.koCatses_ES
dc.subject.koDecerebrate Statees_ES
dc.subject.koElectric Stimulationes_ES
dc.subject.koEnkephalin, Leucine-Analysises_ES
dc.subject.koEnkephalins-Pharmacologyes_ES
dc.subject.koEvoked Potentialses_ES
dc.subject.koHabituation, Psychophysiologic-Drug effectses_ES
dc.subject.koImmunoenzyme Techniqueses_ES
dc.subject.koNaloxone-Pharmacologyes_ES
dc.subject.koReflex-Drug effectses_ES
dc.subject.koSpinal Cord-Analysises_ES
dc.subject.koSpinales_ES
dc.subject.koCord-Physiologyes_ES
dc.subject.koVagotomyes_ES
dc.subject.koEnkephalinses_ES
dc.subject.koNaloxonees_ES
dc.subject.koEnkephalin, Leucinees_ES


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