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The effect of total sleep deprivation on plasma melatonin and cortisol in healthy human volunteers

dc.creatorSalín-Pascual, R.J.
dc.creatorOrtega-Soto, H.
dc.creatorHuerto-Delgadillo, L.
dc.creatorCamacho-Arroyo, I.
dc.creatorRoldán-Roldán, G.
dc.creatorTamarkin, L.
dc.date.accessioned2017-06-29T04:14:04Z
dc.date.available2017-06-29T04:14:04Z
dc.date.issued1988es_ES
dc.identifier70es_ES
dc.identifier.issn0161-8105es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4765
dc.identifier.urihttps://doi.org/10.1093/sleep/11.4.362es_ES
dc.language.isoenges_ES
dc.relation11 (4) 362-369 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleThe effect of total sleep deprivation on plasma melatonin and cortisol in healthy human volunteerses_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Mexicano de Psiquiatría, Departamento de Psicobiología, México City, México.es_ES
dc.relation.jnabreviadoSLEEPes_ES
dc.relation.journalSleepes_ES
dc.identifier.placeUnited Stateses_ES
dc.date.published1988es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.description.monthAgoes_ES
dc.description.abstractotrodiomaTwelve healthy volunteers were included in this study. Baseline curves for melatonin and cortisol were obtained after one night of adaptation to laboratory conditions. From 10:00 p.m. to 6:00 a.m., blood samples were drawn every hour. On the third night, the subjects were kept awake at the sleep unit. Curves for the two hormones were then obtained after 36 h of total sleep deprivation (SD). The levels of these hormones were evaluated by calculating the area under the curve at each hour in both situations (basal and after sleep deprivation). It was found that the melatonin levels were increased after sleep deprivation, whereas the cortisol levels remained the same. These results suggest a mechanism by which a reset of abnormal rhythms can occur in depression.es_ES


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