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Intracellular free magnesium in excitable cells: its measurement and its biologic significance

dc.creatorAlvarez-Leefmans, F.J.
dc.creatorGiraldez, F.
dc.date.accessioned2017-06-29T04:13:49Z
dc.date.available2017-06-29T04:13:49Z
dc.date.issued1987es_ES
dc.identifier55es_ES
dc.identifier.issn0008-4212es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4750
dc.identifier.urihttps://doi.org/10.1139/y87-147es_ES
dc.language.isoenges_ES
dc.relation65 (5) 915-925 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleIntracellular free magnesium in excitable cells: its measurement and its biologic significancees_ES
dc.typearticlees_ES
dc.relation.jnabreviadoCAN J PHYSIOL PHARMACOLes_ES
dc.relation.journalCanadian Journal of Physiology and Pharmacologyes_ES
dc.identifier.placeCanadáes_ES
dc.date.published1987es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1205-7541es_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaAs a necessary cofactor for hundreds of enzymes, intracellular Mg2+ influences a wide range of cellular functions such as transmembrane transport of other ions, glycolysis, respiration, muscle contraction, and phosphorylation of ion channels. Unlike Ca2+, Mg2+ does not seem to have a ‘trigger’ function. However, the wide range of enzymes requiring Mg2+ to be activated suggests that Mg2+ plays a pivotal role in fine control and coordination of cell activity, determining the ‘set point’ of hundreds of metabolic reactions. In this sense, intracellular Mg2+ might be regarded as a static rather than a dynamic regulator of cell function. Little is known about the mechanisms by which excitable and other cells keep their [Mg2+]i within narrow limits against large electrochemical gradients. Furthermore, the actual basal level of [Mg2+]i has been the subject of recent controversy. In the present paper the roles of intracellular Mg2+ on cell function as well as four current techniques for measuring [Mg2+]i are briefly reviewed. These techniques are (i) metallochromic indicators, (ii) 31P nuclear magnetic resonance, (iii) null point for plasma membrane permeabilization using the ionophore A23187 and, (iv) Mg2+-selective microelectrodes. The relative advantages and disadvantages of each of these techniques are discussed with special emphasis on Mg2+-selective microelectrodes.es_ES
dc.subject.koAnimalses_ES
dc.subject.koAzo Compoundses_ES
dc.subject.koBody Fluids-Metabolismes_ES
dc.subject.koCalcimycines_ES
dc.subject.koIntracellular Fluid-Metabolismes_ES
dc.subject.koMagnesium-Analysises_ES
dc.subject.koMagnesium-Physiologyes_ES
dc.subject.koMagnetic Resonance Spectroscopyes_ES
dc.subject.koMicroelectrodeses_ES


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