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Evaluation of the attention and sleepiness states by means of a psychophysiological test of reaction time and time estimate in man: Effects of psychotropic drugs.

dc.creatorFernández-Guardiola, Augusto
dc.creatorJurado, José Luis
dc.creatorAguilar-Jiménez, Efraín
dc.date.accessioned2017-06-29T04:13:29Z
dc.date.available2017-06-29T04:13:29Z
dc.date.issued1984es_ES
dc.identifier32es_ES
dc.identifier.issn0011-393Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4729
dc.language.isoenges_ES
dc.relation35 (6) 1000-1009 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleEvaluation of the attention and sleepiness states by means of a psychophysiological test of reaction time and time estimate in man: Effects of psychotropic drugs.es_ES
dc.typearticlees_ES
dc.contributor.affiliationUnit of Brain Research, National Institute of Neurology and Neurosurgery, and School of Psychology, National Autonomous University of Mexico. Mexico, Mexicoes_ES
dc.relation.jnabreviadoCURR THER RESes_ES
dc.relation.journalCurrent Therapeutic Researches_ES
dc.identifier.placeNew Yorkes_ES
dc.date.published1984es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.description.monthJunes_ES
dc.description.abstractotrodiomaThe hypnotic effect of 4 benzodiazepines (alprazolam, .25 mg ; diazepam 5 mg; ketazolam, 30 mg, and lorazepam, 1 mg) and one placebo ware tested with single doses given 1 hr before the applications of 2 methods: First, polygraphic and behavioral study of wakefulness, sleepiness, and sleep states, and the second, the touch discrimination subtest of Halstead-Reitan neuropsychological test. Eleven volunteer subjects were studied in a crossed double-blind and randomized, analyzing the reaction time, time estimate, failure responses, and predictive responses. A significant increase (p <0.001) of the reaction time and estimate was seen (p<0.002) with the 4 benzodiazepines compared with placebo. The increase of reaction time was accompanied by an increase of failure responses. The best fitting correlation curve between the reaction time and time estime was exponential (r=0.51; n=36; p<0.01). With Halstead-Reitan neuropsychological test no significant alterations were seen, but diazepam produced the greatest impairment and ketazolam the least. At the doses used, the drug with the highest hypnotic action was alprazolam, followed by lorazepam and diazepam. Ketazolam showed an earlier but less-lasting effect.es_ES
dc.subject.koAttentiones_ES
dc.subject.koNeuropsychological Assessmentes_ES
dc.subject.koPsychophysical Measurementes_ES
dc.subject.koReaction Timees_ES
dc.subject.koTactual Perceptiones_ES
dc.subject.koBenzodiazepineses_ES
dc.subject.koConsciousness Stateses_ES
dc.subject.koElectrophysiologyes_ES
dc.subject.koSleepinesses_ES
dc.subject.koTime Estimationes_ES
dc.subject.koVisual Stimulationes_ES


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