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Brain content of Leu5-and met5-enkephalin changes independently during the development kindling in the rat

dc.creatorVindrola, Osvaldo
dc.creatorBriones, Rafael
dc.creatorAsai, Miguel
dc.creatorFernández-Guardiola, Augusto
dc.date.accessioned2017-06-29T04:13:15Z
dc.date.available2017-06-29T04:13:15Z
dc.date.issued1981es_ES
dc.identifier14es_ES
dc.identifier.issn0304-3940es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4712
dc.identifier.urihttps://doi.org/10.1016/0304-3940(81)90337-2
dc.language.isoenges_ES
dc.relation26 (2) 125-130 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleBrain content of Leu5-and met5-enkephalin changes independently during the development kindling in the rates_ES
dc.typearticlees_ES
dc.contributor.affiliationUnidad de Investigaciones Cerebrales, Instituto Nacional de Neurología y Neurocirugía, lnsurgentes Sur No. 3877, México 22 D.F. (México)es_ES
dc.relation.jnabreviadoNEUROSCI LETTes_ES
dc.relation.journalNeuroscience Letterses_ES
dc.identifier.placeLimerickes_ES
dc.date.published1981es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaBrain content of leucine-enkephalin and methionine-enkephalin changes independently during kindling of the amygdala. Both peptides were measured after 4, 8, 15 and 21 days of stimulation. Leuenkephalin showed a progressive increase during the kindling: the results on the 4th day did not differ significantly from the controls, whereas those on the 8th day displayed an increase only in the stimulated left hemisphere and those on the 15th day showed an increase in both hemispheres. This increase was also seen after 21 days of stimulation. In contrast, Met-enkephalin was not modified during the early stages of kindling, but was found to be increased after the animals had presented five or more generalized seizures. These results show that Leu-enkephalin is related to the development of kindling, whereas Metenkephalin levels change only as a consequence of the generalized seizures.es_ES
dc.subject.kwRatases_ES
dc.subject.kwCerebroes_ES
dc.subject.kwEstimulaciónes_ES
dc.subject.kwConvulsiones generalizadases_ES
dc.subject.koRatses_ES
dc.subject.koBraines_ES
dc.subject.koStimulationes_ES
dc.subject.koGeneralized seizureses_ES


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