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Neuroprotective role of estradiol against neuronal death induced by glucose deprivation in cultured rat hippocampal neurons

dc.creatorHernández-Fonseca, Karla
dc.creatorMassieu, Lourdes
dc.creatorGarcía de la Cadena, Selene
dc.creatorGuzmán, Carolina
dc.creatorCamacho-Arroyo, Ignacio
dc.date.accessioned2017-06-29T04:01:28Z
dc.date.available2017-06-29T04:01:28Z
dc.date.issued2012es_ES
dc.identifier2847es_ES
dc.identifier.issn0028-3835es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4696
dc.identifier.urihttps://doi.org/10.1159/000334229es_ES
dc.language.isoenges_ES
dc.publisherBasel : Kargeres_ES
dc.relation96 (1) 41-50 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshCell Death-Drug effectses_ES
dc.subject.meshCells, Culturedes_ES
dc.subject.meshEstradiol-Pharmacologyes_ES
dc.subject.meshEstrogen Receptor alpha-Agonistses_ES
dc.subject.meshEstrogen Receptor beta-Agonistses_ES
dc.subject.meshGlucose-Metabolismes_ES
dc.subject.meshHippocampus-Cytologyes_ES
dc.subject.meshHippocampus-Drug effectses_ES
dc.subject.meshHippocampus-Metabolismes_ES
dc.subject.meshNeurons-Cytologyes_ES
dc.subject.meshNeurons-Drug effectses_ES
dc.subject.meshNeurons-Metabolismes_ES
dc.subject.meshNeuroprotective Agents-Pharmacologyes_ES
dc.subject.meshNitriles-Pharmacologyes_ES
dc.subject.meshPropionates-Pharmacologyes_ES
dc.subject.meshPyrazoles-Pharmacologyes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.titleNeuroprotective role of estradiol against neuronal death induced by glucose deprivation in cultured rat hippocampal neuronses_ES
dc.typeartículoes_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente, Departamento de Neuropatología Molecular,es_ES
dc.contributor.emailcamachoarroyo @ gmail.comes_ES
dc.relation.jnabreviadoNEUROENDOCRINOLOGYes_ES
dc.relation.journalNeuroendocrinologyes_ES
dc.identifier.placeSuizaes_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1423-0194es_ES
dc.identifier.doi10.1159/000334229es_ES
dc.description.abstractotrodiomaStudies have reported the protective effect of estradiol (E(2)) against neuronal death induced by several insults including oxygen deprivation, mitochondrial toxins and activation of glutamate receptors. Glucose deprivation (GD) is associated with ischemia and hypoglycemia, and to date there is no effective therapeutic agent able to prevent neuronal damage induced by these conditions. In this study, we have investigated the effects of 17β-E(2) and the selective agonists of the alpha (ERα) and beta (ERβ) estrogen receptors, propyl pyrazole triol (PPT) and diarylpropionitrile (DPN), respectively, on neuronal death induced by GD in cultured rat hippocampal neurons. We have also analyzed the expression of both ER isoforms after GD. Results show that GD for 2 and 4 h reduces cell survival by 42 and 55%, respectively. Treatment with 17β-E(2) (10 nM to 10 µM) induces a dose-dependent protective effect that is blocked by ICI 182,780, an ER antagonist, and by 1,3-bis(4-hydroxyphenyl)-4-methyl-5-[4-(-piperidinylethoxy)phenol]-1H'pyrazole dihydrochloride (MPP) and 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol (PHTPP), selective ERα and ERβ antagonists, respectively. The ERα and ERβ agonists PPT and DPN show a similar neuroprotective effect to that of 17β-E(2), but DPN is more efficient. In addition, hippocampal neurons under normal conditions show a higher expression of the ERβ isoform. When exposed to GD during 4 h, the expression of both ER isoforms is increased, while only that of the ERβ isoform significantly increases after 2 h of GD. Results demonstrate that E(2) prevents neuronal death induced by GD through its interaction with ER, although the ERβ isoform might have a predominant role. Results also suggest that GD differentially alters the expression of ERα and ERβ in hippocampal neurons.es_ES
dc.subject.koEstradioles_ES
dc.subject.koHippocampuses_ES
dc.subject.koGlucose deprivationes_ES
dc.subject.koNeuronal deathes_ES
dc.subject.koNeuroprotectiones_ES
dc.subject.koEstrogen receptorses_ES


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