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Nerol alleviates pathologic markers in the oxazolone-induced colitis model

dc.creatorGonzález-Ramírez, Adriana Estrella
dc.creatorGonzález-Trujano, María Eva
dc.creatorOrozco-Suárez, Sandra A.
dc.creatorAlvarado-Vásquez, Noé
dc.creatorLópez-Muñoz, Francisco Javier
dc.date.accessioned2017-06-29T04:01:10Z
dc.date.available2017-06-29T04:01:10Z
dc.date.issued2016es_ES
dc.identifier2844es_ES
dc.identifier.issn0014-2999es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/j.ejphar.2016.02.036es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4693
dc.language.isoenges_ES
dc.publisherAmsterdam : Elsevier Sciencees_ES
dc.relation776, 81-89 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleNerol alleviates pathologic markers in the oxazolone-induced colitis modeles_ES
dc.typeartículoes_ES
dc.contributor.affiliationDepartamento de Farmacobiología, CINVESTAV Sur, Calzada de los Tenorios 235, Col. Granjas Coapa, C.P. 14330 México, D.F., Mexicoes_ES
dc.contributor.emailevag@imp.edu.mxes_ES
dc.relation.jnabreviadoEUR J PHARMACOLes_ES
dc.relation.journalEuropean Journal of Pharmacologyes_ES
dc.identifier.placePaíses Bajoses_ES
dc.date.published2016es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1879-0712es_ES
dc.identifier.doi10.1016/j.ejphar.2016.02.036es_ES
dc.description.monthAbres_ES
dc.description.abstractotrodiomaNerol is a natural monoterpene with antinociceptive and anti-inflammatory properties. Its possible beneficial effects in ulcerative colitis and its corresponding mechanism faction have not been determined to date. The aim of this study was to investigate whether nerol prevents the appearance of pathological markers and hyperalgesia in oxazolone-induced colitis, and protects against gastric damage produced by ethanol. The experimental design included groups of oxazolone-treated mice receiving nerol at10–300mg/kg, p.o., or a reference drug (sulfasalazine,100mg/kg,p.o.) compared to sham and untreated groups. Gastric damage was evaluated in the absolute ethanol-induced ulcer model in rats. Variables measured in animals with oxazolone-induced colitis included weight loss, stool consistency and macroscopic colon damage; mechanical nociception was determined by the use of von Frey fila-ments, whereas levels of inflammatory cytokines were assessed by enzyme-linked immunosorbent assay. Nerol (30_300 mg/kg, p.o.) prevented or significantly decreased the pathological alterations observed in the oxazolone-induced colitis model. It also showed antinociceptive effects and reduced the increased levels of inflammatory cytokines (IL-13 and TNF-α). Gastric damage was also prevented starting at 10 mg/kg, p.o. In conclusion,our results provide evidence for a beneficial effect of nerol after colitis induction involving tissue protection, antinociception and modulation of the immunological system, suggesting the therapeutic potential of this monoterpene as a novel alternative in controlling ulcerative colitises_ES
dc.subject.koGastroprotectiones_ES
dc.subject.koInflammatory cytokineses_ES
dc.subject.koNeroles_ES
dc.subject.koOxazolonees_ES
dc.subject.koUlcerative colitises_ES


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