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Neocortical hyperexcitability after GABA withdrawal in vitro

dc.creatorCalixto, E.
dc.creatorLo´pez-Colome, A.M.
dc.creatorCasasola, C.
dc.creatorMontiel, T.
dc.creatorBargas, J.
dc.creatorBrailowsky, S.
dc.date2000
dc.date.accessioned2017-06-29T04:01:04Z
dc.date.available2017-06-29T04:01:04Z
dc.date.issued2000
dc.identifier2843es_ES
dc.identifier.issn0920-1211es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4692es_ES
dc.identifier.urihttps://doi.org/10.1016/S0920-1211(99)00100-Xes_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisherAmsterdam : Elsevier Science Publisherses_ES
dc.relation39 (1) 13-26 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshFlunitrazepam/adverse effectses_ES
dc.subject.meshGABA Agonists/metabolismes_ES
dc.subject.meshGABA Modulators/adverse effectses_ES
dc.subject.meshMuscimol/metabolismes_ES
dc.subject.meshNeocortex/drug effectses_ES
dc.subject.meshNeocortex/metabolismes_ES
dc.subject.meshPregnanolone/adverse effectses_ES
dc.subject.meshProgesterone/adverse effectses_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshSeizures/chemically inducedes_ES
dc.subject.meshSeizures/metabolismes_ES
dc.subject.meshSubstance Withdrawal Syndrome/metabolismes_ES
dc.subject.meshSynaptic Transmission/drug effectses_ES
dc.subject.meshSynaptic Transmission/physiologyes_ES
dc.subject.meshgamma-Aminobutyric Acid/adverse effectses_ES
dc.subject.meshgamma-Aminobutyric Acid/pharmacokineticses_ES
dc.titleNeocortical hyperexcitability after GABA withdrawal in vitroes_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationInstituto de Fisiología Celular, UNAM, P.O. Box 70-253, Mexico City DF 04510, Mexicoes_ES
dc.contributor.emailjbargas@ifisiol.unam.mxes_ES
dc.relation.jnabreviadoEPILEPSY RESes_ES
dc.relation.journalEpilepsy Researches_ES
dc.identifier.placePaíses Bajoses_ES
dc.date.published2000es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-6844es_ES
dc.identifier.doies_ES
dc.description.monthMares_ES
dc.description.abstractotrodiomaThe sharp interruption of the intracortical instillation of exogenous g-aminobutyric acid (GABA), generates an epileptic focus in mammals. Seizures elicited by GABA withdrawal last several days or weeks. The present work reports that GABA withdrawal-induced hyperexcitability can be produced in vitro: a sudden withdrawal of GABA (5 mM; 120 min) or benzodiazepine (60 mM flunitrazepam) from the superfusion, induced a gradual increase in the amplitude of the evoked population spike (PS) recorded on neocortical slices. PS enhancement reached 150% above the control value 2.5 h after GABA withdrawal. GABA withdrawal-induced hyperexcitability was facilitated by progesterone. PS enhancement induced by GABA withdrawal was associated with an impairment of GABA transmission occurring before epileptiform discharges were fully established. Paired pulse inhibition and evoked [ 3 H]-GABA release appear decreased; suggesting that cortical hyperexcitability as a result of GABA withdrawal involves pre-synaptic changes. Specific muscimol binding decreased during GABA superfusion but recovered after GABA withdrawal. However, the sensitivity of the post-synaptic response to 3a-OH-5a-pregnan-20-one or allopregnanolone (alloP) was enhanced after GABA withdrawal, suggesting a functional change in the GABAA receptors. The changes described may be the cellular correlates of the withdrawal syndromes appearing after interruption of the administration of GABAA receptor agonists.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koGABAes_ES
dc.subject.koGABAA receptores_ES
dc.subject.koEpilepsyes_ES
dc.subject.koNeurosteroidses_ES
dc.subject.koWithdrawales_ES
dc.subject.koHyperexcitabilityes_ES


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